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Research ArticleArticle

The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites

Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder
Drug Metabolism and Disposition November 2020, 48 (11) 1113-1120; DOI: https://doi.org/10.1124/dmd.120.000188
Brian D. Chapron
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
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Jean C. Dinh
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
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Paul C. Toren
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
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Andrea Gaedigk
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
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  • ORCID record for Andrea Gaedigk
J. Steven Leeder
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
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Article Information

vol. 48 no. 11 1113-1120
DOI 
https://doi.org/10.1124/dmd.120.000188
PubMed 
32847865

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 20, 2020
  • Accepted August 10, 2020
  • Published online October 12, 2020.

Article Versions

  • Earlier version (August 26, 2020 - 16:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Brian D. Chapron,
  2. Jean C. Dinh,
  3. Paul C. Toren,
  4. Andrea Gaedigk, and
  5. J. Steven Leeder
  1. Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Kansas City, Kansas City, Missouri
  1. Address correspondence to:
    Brian D. Chapron, Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children’s Mercy Kansas City, 2401 Gillham Rd., Kansas City, MO 64108. E-mail: bchapron{at}cmh.edu
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Drug Metabolism and Disposition: 48 (11)
Drug Metabolism and Disposition
Vol. 48, Issue 11
1 Nov 2020
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Research ArticleArticle

Roles of CYP2D6 and CYP3A4 in Pimozide Metabolism

Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder
Drug Metabolism and Disposition November 1, 2020, 48 (11) 1113-1120; DOI: https://doi.org/10.1124/dmd.120.000188

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Research ArticleArticle

Roles of CYP2D6 and CYP3A4 in Pimozide Metabolism

Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder
Drug Metabolism and Disposition November 1, 2020, 48 (11) 1113-1120; DOI: https://doi.org/10.1124/dmd.120.000188
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