Table of Contents

Articles

• Open Access

  Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals

  Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen

  Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145
• 

  Open Access

  Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability

  Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu

  Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207
• Open Access

  Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models

  Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik

  Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149
• You have access

  Scaling Factors for Clearance in Adult Liver Cirrhosis

  Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan

  Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152
• You have access

  In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation

  Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai

  Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163
• Open Access

  Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure

  Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi

  Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127
• You have access

  A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity

  Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

  Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098
• Open Access

  Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite

  David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin

  Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103
• You have access

  Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis

  Parimal Pande, Xiao-bo Zhong and Warren W. Ku

  Drug Metabolism and Disposition December 2020, 48 (12) 1321-1329; DOI: https://doi.org/10.1124/dmd.120.000195
• You have access

  In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans

  Chevalier Clémence, Pascale Fouqueray and Bolze Sébastien

  Drug Metabolism and Disposition December 2020, 48 (12) 1330-1346; DOI: https://doi.org/10.1124/dmd.120.000154
• You have access

  In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes

  Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen

  Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171
• You have access

  Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey

  Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones

  Drug Metabolism and Disposition December 2020, 48 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.120.000187
• 

  You have access

  Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD⁺ in the Liver

  Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma

  Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139
• You have access

  Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations

  Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov

  Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170