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Drug Metabolism & Disposition

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Table of Contents

December 01, 2020; Volume 48,Issue 12

Articles

  • Open Access
    Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
    Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
    Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145
  • Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
    Open Access
    Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
    Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu
    Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207
  • Open Access
    Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
    Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
    Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149
  • You have access
    Scaling Factors for Clearance in Adult Liver Cirrhosis
    Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152
  • You have access
    In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
    Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
    Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163
  • Open Access
    Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
    Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
    Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127
  • You have access
    A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
    Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
    Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098
  • Open Access
    Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
    David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
    Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103
  • You have access
    Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis
    Parimal Pande, Xiao-bo Zhong and Warren W. Ku
    Drug Metabolism and Disposition December 2020, 48 (12) 1321-1329; DOI: https://doi.org/10.1124/dmd.120.000195
  • You have access
    In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans
    Chevalier Clémence, Pascale Fouqueray and Bolze Sébastien
    Drug Metabolism and Disposition December 2020, 48 (12) 1330-1346; DOI: https://doi.org/10.1124/dmd.120.000154
  • You have access
    In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
    Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
    Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171
  • You have access
    Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
    Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones
    Drug Metabolism and Disposition December 2020, 48 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.120.000187
  • Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
    You have access
    Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
    Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
    Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139
  • You have access
    Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
    Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
    Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

Errata

  • You have access
    Correction to “Gestational Age–Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics”
    Drug Metabolism and Disposition December 2020, 48 (12) 1347; DOI: https://doi.org/10.1124/dmd.120.000067err
  • You have access
    Correction to “Characterization of Seasonal Pharmacokinetic Variability in Woodchucks”
    Drug Metabolism and Disposition December 2020, 48 (12) 1348-1349; DOI: https://doi.org/10.1124/dmd.120.000140err
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Drug Metabolism and Disposition: 48 (12)
Drug Metabolism and Disposition
Vol. 48, Issue 12
1 Dec 2020
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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