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Index by author

December 01, 2020; Volume 48,Issue 12

A

  1. Abbasi, Armina

    1. Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
      Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones
      Drug Metabolism and Disposition December 2020, 48 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.120.000187

  2. Achour, Brahim

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

  3. Al-Majdoub, Zubida M.

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

  4. Athwal, Varinder

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

B

  1. Barber, Jill

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

  2. Barnes, Chris N.

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

  3. Borin, Marie T.

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

  4. Bourdet, David L.

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

  5. Brockmöller, Jürgen

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  6. Bui, Annamaria

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

C

  1. Callegari, Ernesto

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  2. Cheung, Kit Wun Kathy

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  3. Chiba, Koji

    1. Open Access
      Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
      Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
      Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127

  4. Cianfrogna, Julie

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  5. Clémence, Chevalier

    1. In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans
      Chevalier Clémence, Pascale Fouqueray and Bolze Sébastien
      Drug Metabolism and Disposition December 2020, 48 (12) 1330-1346; DOI: https://doi.org/10.1124/dmd.120.000154

  6. Colson, Pierre-Jean

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

D

  1. DeForest, Natalie

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

E

  1. El-Khateeb, Eman

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

F

  1. Farasyn, Taleah

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  2. Figueroa, Isabel

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  3. Fouqueray, Pascale

    1. In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans
      Chevalier Clémence, Pascale Fouqueray and Bolze Sébastien
      Drug Metabolism and Disposition December 2020, 48 (12) 1330-1346; DOI: https://doi.org/10.1124/dmd.120.000154

G

  1. Gáborik, Zsuzsanna

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  2. Gaedcke, Jochen

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  3. Goosen, Theunis C.

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  4. Grant, Denis M.

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

H

  1. Hao, Jia

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  2. Hegde, Sharath S.

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

J

  1. Jilek, Joseph L.

    1. Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Open Access
      Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu
      Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207

  2. Jones, Jeffrey P.

    1. Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
      Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones
      Drug Metabolism and Disposition December 2020, 48 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.120.000187

  3. Joswig-Jones, Carolyn A.

    1. Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
      Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones
      Drug Metabolism and Disposition December 2020, 48 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.120.000187

K

  1. Kamath, Amrita

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  2. Kelly, Edward J.

    1. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
      Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
      Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098

  3. Kis, Emese

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  4. Kovács, Péter

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  5. Ku, Warren W.

    1. Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis
      Parimal Pande, Xiao-bo Zhong and Warren W. Ku
      Drug Metabolism and Disposition December 2020, 48 (12) 1321-1329; DOI: https://doi.org/10.1124/dmd.120.000195

  6. Kurosawa, Ken

    1. Open Access
      Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
      Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
      Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127

L

  1. Lai, Yurong

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  2. Lapham, Kimberly

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  3. Latifi, Brandon

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  4. Leipold, Doug

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  5. Li, Jianhua

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

  6. Li, Ruina

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  7. Liang, Xiaomin

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  8. Lin, Jian

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  9. Liu, Ke

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

  10. Lu, Jie

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

M

  1. Ma, Xiaochao

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

  2. Masih, Shab

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  3. Meyer, Marleen J.

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  4. Musib, Luna

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

N

  1. Ng, Carl

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  2. Nieskens, Tom T.G.

    1. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
      Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
      Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098

  3. Niosi, Mark

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  4. Nishimura, Tomohiro

    1. Open Access
      Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
      Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
      Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127

  5. Niu, Congrong

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  6. Noguchi, Saki

    1. Open Access
      Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
      Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
      Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127

O

  1. Orozco, Christine C.

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  2. Oswald, Stefan

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

P

  1. Pande, Parimal

    1. Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis
      Parimal Pande, Xiao-bo Zhong and Warren W. Ku
      Drug Metabolism and Disposition December 2020, 48 (12) 1321-1329; DOI: https://doi.org/10.1124/dmd.120.000195

  2. Park, Yeojin

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  3. Persson, Mikael

    1. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
      Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
      Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098

  4. Plise, Emile

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

R

  1. Römer, Sarah

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  2. Rostami-Hodjegan, Amin

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

S

  1. Sane, Rucha

    1. Open Access
      Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
      Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
      Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

  2. Scotcher, Daniel

    1. Scaling Factors for Clearance in Adult Liver Cirrhosis
      Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition December 2020, 48 (12) 1271-1282; DOI: https://doi.org/10.1124/dmd.120.000152

  3. Sébastien, Bolze

    1. In Vitro Investigation, Pharmacokinetics, and Disposition of Imeglimin, a Novel Oral Antidiabetic Drug, in Preclinical Species and Humans
      Chevalier Clémence, Pascale Fouqueray and Bolze Sébastien
      Drug Metabolism and Disposition December 2020, 48 (12) 1330-1346; DOI: https://doi.org/10.1124/dmd.120.000154

  4. Seitz, Tina

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  5. Sharma, Raman

    1. In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
      Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen
      Drug Metabolism and Disposition December 2020, 48 (12) 1350-1363; DOI: https://doi.org/10.1124/dmd.120.000171

  6. Shen, Ben-Quan

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  7. Sjögren, Anna-Karin

    1. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
      Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
      Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098

  8. Smith, Bill

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

T

  1. Tomi, Masatoshi

    1. Open Access
      Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
      Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi
      Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127

  2. Tu, Mei-Juan

    1. Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Open Access
      Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu
      Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207

  3. Tuerkova, Alzbeta

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  4. Tung, Hung-Chun

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

  5. Tzvetkov, Mladen V.

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

W

  1. Wang, Kelly

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  2. Wenzel, Christoph

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

X

  1. Xie, Wen

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139

Y

  1. Yeola, Suresh

    1. Open Access
      Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite
      David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin
      Drug Metabolism and Disposition December 2020, 48 (12) 1312-1320; DOI: https://doi.org/10.1124/dmd.120.000103

  2. Yip, Victor

    1. Open Access
      Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
      Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen
      Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145

  3. Yu, Ai-Ming

    1. Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Open Access
      Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu
      Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207

Z

  1. Zdrazil, Barbara

    1. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations
      Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jürgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov
      Drug Metabolism and Disposition December 2020, 48 (12) 1380-1392; DOI: https://doi.org/10.1124/dmd.120.000170

  2. Zhang, Chao

    1. Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Open Access
      Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
      Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu
      Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207

  3. Zhao, Xiaofeng

    1. In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation
      Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill Smith and Yurong Lai
      Drug Metabolism and Disposition December 2020, 48 (12) 1283-1292; DOI: https://doi.org/10.1124/dmd.120.000163

  4. Zhong, Xiao-bo

    1. Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis
      Parimal Pande, Xiao-bo Zhong and Warren W. Ku
      Drug Metabolism and Disposition December 2020, 48 (12) 1321-1329; DOI: https://doi.org/10.1124/dmd.120.000195

  5. Zhu, Junjie

    1. Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver
      Cell Type–Specific Roles of CD38 in the Interactions of Isoniazid with NAD+ in the Liver
      Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma
      Drug Metabolism and Disposition December 2020, 48 (12) 1372-1379; DOI: https://doi.org/10.1124/dmd.120.000139
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