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Research ArticleArticle
Open Access

Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models

Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149
Rucha Sane
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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  • For correspondence: sane.rucha@gene.com
Kit Wun Kathy Cheung
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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  • ORCID record for Kit Wun Kathy Cheung
Péter Kovács
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Taleah Farasyn
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Ruina Li
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Annamaria Bui
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Luna Musib
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Emese Kis
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Emile Plise
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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Zsuzsanna Gáborik
Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
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  • For correspondence: zsuzsanna.gaborik@crl.com
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Article Information

vol. 48 no. 12 1264-1270
DOI 
https://doi.org/10.1124/dmd.120.000149
PubMed 
33037044

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 15, 2020
  • Accepted September 28, 2020
  • Published online November 16, 2020.

Article Versions

  • Earlier version (October 9, 2020 - 06:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Rucha Sane⇑,
  2. Kit Wun Kathy Cheung,
  3. Péter Kovács,
  4. Taleah Farasyn1,
  5. Ruina Li,
  6. Annamaria Bui,
  7. Luna Musib,
  8. Emese Kis,
  9. Emile Plise, and
  10. Zsuzsanna Gáborik⇑
  1. Departments of Clinical Pharmacology (R.S., K.W.K.C., T.F., L.M.) and Drug Metabolism and Pharmacokinetics (T.F., R.L., E.P.), Genentech, Inc., South San Francisco, California; and SOLVO Biotechnology, Budapest, Hungary (P.K., A.B., E.K., Z.G.)
  1. Address correspondence to:
    Dr. Rucha Sane, Department of Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. E-mail: sane.rucha{at}gene.com; or
  2. Dr. Zsuzsanna Gáborik, SOLVO Biotechnology, Irinyi Jozsef u 4-20, Budapest 1117, Hungary. E-mail: zsuzsanna.gaborik{at}crl.com
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Drug Metabolism and Disposition: 48 (12)
Drug Metabolism and Disposition
Vol. 48, Issue 12
1 Dec 2020
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Research ArticleArticle

Transporter-Mediated Rosuvastatin DDI Prediction

Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
Drug Metabolism and Disposition December 1, 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149

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Research ArticleArticle

Transporter-Mediated Rosuvastatin DDI Prediction

Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik
Drug Metabolism and Disposition December 1, 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149
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