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A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098

Article Information

vol. 48 no. 12 1303-1311
DOI 
https://doi.org/10.1124/dmd.120.000098
PubMed 
33020068
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 24, 2020
  • Accepted September 23, 2020
  • Published online November 18, 2020.

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Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tom T.G. Nieskens1,
  2. Mikael Persson1,
  3. Edward J. Kelly2,3, and
  4. Anna-Karin Sjögren1
  1. CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden (T.T.G.N., M.P., A.-K.S.) and Department of Pharmaceutics and Kidney Research Institute, University of Washington, Seattle, Washington (E.J.K.)
  1. Address correspondence to:
    Anna-Karin Sjögren, AstraZeneca R&D Mölndal, Pepparedsleden 1, 43150 Mölndal, Sweden. E-mail: anna-karin.sjogren{at}astrazeneca.com
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Polarization Determines Kidney-on-a-Chip Cisplatin Toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
Drug Metabolism and Disposition December 1, 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098
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