Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplementary Table 1 - Enzyme kinetics of Abi, D4A and 5α-Abi glucuronidation by UGT1A4 alloenzymes.
Supplementary Figure 1 - Structures of compounds relevant to this stud.
Supplementary Figure 2 - Eadie-Hofstee regressions for the formation of glucuronides of Abi by human liver microsomes (HLM) and recombinant UGT1A4 enzyme.
Supplementary Figure 3 - Eadie-Hofstee regressions for the formation of glucuronides of D4A and 5α-Abi by human liver microsomes (HLM) and recombinant UGT1A4 enzyme.
Supplementary Figure 4 - Eadie-Hofstee regressions for the formation of glucuronides of Gal by human liver microsomes (HLM) and recombinant UGT1A4 enzyme.
Supplementary Figure 5 - Dose-dependent inhibition of drug glucuronide formation by Abi, D4A, 5α-Abi in human liver microsomes (HLM) (A, C, E) and recombinant UGT1A4 enzyme (B, D, F).
Supplementary Figure 6 - Dose-dependent inhibition of glucuronidation of adrenal precursors (DHEA and A5-diol) and androgens (Testo and DHT) by D4A, 5α-Abi and Gal in human liver microsomes (HLM) (A, C, E) and recombinant UGT1A4 enzyme (B, D, F).
Supplementary Figure 7 - Lineweaver-Burk plots for inhibition of drug glucuronidation by hecogenin in human liver microsomes (HLM) (left) and recombinant UGT1A4 enzyme (right).
Supplementary Figure 8 - Lineweaver-Burk plots for inhibition of glucuronidation of adrenal precursors (DHEA and A5-diol) and androgens (Testo and DHT) by Abi in human liver microsomes (HLM) (right) and recombinant UGT1A4 enzyme (left).
- Supplemental Data -