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Drug Metabolism & Disposition

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Table of Contents

May 01, 2020; Volume 48,Issue 5

Minireview

  • Open Access
    Ontogeny and Cross-species Comparison of Pathways Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Neonates (Review): Kidney
    Ruud Bueters, An Bael, Elke Gasthuys, Connie Chen, Michiel F. Schreuder and Kendall S. Frazier
    Drug Metabolism and Disposition May 2020, 48 (5) 353-367; DOI: https://doi.org/10.1124/dmd.119.089755
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    Circadian Clock–Controlled Drug Metabolism: Implications for Chronotherapeutics
    Danyi Lu, Mengjing Zhao, Min Chen and Baojian Wu
    Drug Metabolism and Disposition May 2020, 48 (5) 395-406; DOI: https://doi.org/10.1124/dmd.120.090472

Articles

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    Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver
    Yifan Bao, Pei Wang, Xueyan Shao, Junjie Zhu, Jingcheng Xiao, Jian Shi, Lirong Zhang, Hao-Jie Zhu, Xiaochao Ma, José E. Manautou and Xiao-bo Zhong
    Drug Metabolism and Disposition May 2020, 48 (5) 326-336; DOI: https://doi.org/10.1124/dmd.119.089557
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    Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function
    Misgana Idris, Deanne J. Mitchell, Richard Gordon, Neelima P. Sidharthan, Neville J. Butcher and Rodney F. Minchin
    Drug Metabolism and Disposition May 2020, 48 (5) 337-344; DOI: https://doi.org/10.1124/dmd.119.089714
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    Theophylline Acetaldehyde as the Initial Product in Doxophylline Metabolism in Human Liver
    Xiaohua Zhao, Hong Ma, Qiusha Pan, Haiyi Wang, Xingkai Qian, Peifang Song, Liwei Zou, Mingqing Mao, Shuyue Xia, Guangbo Ge and Ling Yang
    Drug Metabolism and Disposition May 2020, 48 (5) 345-352; DOI: https://doi.org/10.1124/dmd.119.089565
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    Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells
    Sharad Sharma, Zhe Li, David Bussing and Dhaval K. Shah
    Drug Metabolism and Disposition May 2020, 48 (5) 368-377; DOI: https://doi.org/10.1124/dmd.119.089276
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    Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine
    Sunil Veeravalli, Ian R. Phillips, Rafael T. Freire, Dorsa Varshavi, Jeremy R. Everett and Elizabeth A. Shephard
    Drug Metabolism and Disposition May 2020, 48 (5) 378-385; DOI: https://doi.org/10.1124/dmd.119.089995
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    Alteration in the Plasma Concentrations of Endogenous Organic Anion–Transporting Polypeptide 1B Biomarkers in Patients with Non–Small Cell Lung Cancer Treated with Paclitaxel
    Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Sojiro Kusumoto, Yusuke Kondo, Saki Izumi, Genki Nakata, Yoshitane Nozaki, Kazuya Maeda, Yasutsuna Sasaki, Ken-ichi Fujita and Hiroyuki Kusuhara
    Drug Metabolism and Disposition May 2020, 48 (5) 387-394; DOI: https://doi.org/10.1124/dmd.119.089474
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    Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947
    Xingrong Liu, Xiaorong Liang, Jenninfer LeCouter, Savita Ubhayakar, Jacob Chen, Jay Cheng, Tom Lee, Joe Lubach, Jim Nonomiya, Sheerin Shahidi-Latham, Cristine Quiason, Eric Solon, Matthew Wright, Cornelis E.C.A. Hop and Timothy P. Heffron
    Drug Metabolism and Disposition May 2020, 48 (5) 408-418; DOI: https://doi.org/10.1124/dmd.119.089763
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    Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions
    Mingqing Chen, Shuiying Hu, Yang Li, Alice A. Gibson, Qiang Fu, Sharyn D. Baker and Alex Sparreboom
    Drug Metabolism and Disposition May 2020, 48 (5) 419-425; DOI: https://doi.org/10.1124/dmd.119.090316

Errata

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    Correction to “Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells”
    Drug Metabolism and Disposition May 2020, 48 (5) 386; DOI: https://doi.org/10.1124/dmd.119.090043err
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    Correction to “Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine”
    Drug Metabolism and Disposition May 2020, 48 (5) 407; DOI: https://doi.org/10.1124/dmd.119.089656err
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In this issue

Drug Metabolism and Disposition: 48 (5)
Drug Metabolism and Disposition
Vol. 48, Issue 5
1 May 2020
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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