Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Table -
Supplementary Table 1 - 336 DMET genes obtained from Pharmapendium and indication whether gene expression data is available in NCBI Gene Expression Omnibus database with accession GEO21335.
- Supplemental Table 2 -
Supplementary Table 2 - 29 DMET genes whose gene expressions are significantly different in females and males (absolute fold change, F/M) at all 4 adult ages (8, 15, 21 and 52 weeks) along with drugs which are metabolized by them (source - Pharmapendium.
- Supplemental Table 3 -
Supplementary Table 3 - Cmax values for 33 drugs metabolized by 1 or 2 Cyps encoded by sexually dimorphic mRNAs that were tested for cytotoxicity in primary rat hepatocytes.
- Supplemental Figures -
Supplementary Figure 1 - Real-time quantitative PCR measurement Cyp mRNAs in untreated cultures of attached primary hepatocytes derived from male (solid line) and female (dashed line) F344 rats.
Supplementary Figure 2 - Western blot analysis of CYP proteins in untreated cultures of attached primary hepatocytes derived from male and female F344 rats.
- Supplemental Table -