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Research ArticleArticle

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

John T. Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock and Larry C. Wienkers
Drug Metabolism and Disposition June 2020, 48 (6) 508-514; DOI: https://doi.org/10.1124/dmd.119.089813

Article Information

vol. 48 no. 6 508-514
DOI 
https://doi.org/10.1124/dmd.119.089813
PubMed 
32193357
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 24, 2019
  • Accepted February 21, 2020
  • Published online May 19, 2020.

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Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. John T. Barr,
  2. Zhican Wang,
  3. Xiaoshan Min,
  4. Henry J. Wienkers,
  5. Brooke M. Rock,
  6. Dan A. Rock, and
  7. Larry C. Wienkers
  1. Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
  1. Address correspondence to:
    Dan A. Rock, Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veteran’s Blvd., South San Francisco, CA 94080. E-mail: drock{at}amgen.com
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Research ArticleArticle

CYP3A4 Time-Dependent Inhibition by Cysteine-Targeting Electrophiles

John T. Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock and Larry C. Wienkers
Drug Metabolism and Disposition June 1, 2020, 48 (6) 508-514; DOI: https://doi.org/10.1124/dmd.119.089813
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