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Research ArticleArticle

Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

John T. Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock and Larry C. Wienkers
Drug Metabolism and Disposition June 2020, 48 (6) 508-514; DOI: https://doi.org/10.1124/dmd.119.089813
John T. Barr
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Zhican Wang
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Xiaoshan Min
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Henry J. Wienkers
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Brooke M. Rock
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Dan A. Rock
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Larry C. Wienkers
Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
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Article Information

vol. 48 no. 6 508-514
DOI 
https://doi.org/10.1124/dmd.119.089813
PubMed 
32193357

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 24, 2019
  • Accepted February 21, 2020
  • Published online May 19, 2020.

Article Versions

  • Earlier version (March 19, 2020 - 16:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. John T. Barr,
  2. Zhican Wang,
  3. Xiaoshan Min,
  4. Henry J. Wienkers,
  5. Brooke M. Rock,
  6. Dan A. Rock, and
  7. Larry C. Wienkers
  1. Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
  1. Address correspondence to:
    Dan A. Rock, Amgen Research, Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veteran’s Blvd., South San Francisco, CA 94080. E-mail: drock{at}amgen.com
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Drug Metabolism and Disposition: 48 (6)
Drug Metabolism and Disposition
Vol. 48, Issue 6
1 Jun 2020
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Research ArticleArticle

CYP3A4 Time-Dependent Inhibition by Cysteine-Targeting Electrophiles

John T. Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock and Larry C. Wienkers
Drug Metabolism and Disposition June 1, 2020, 48 (6) 508-514; DOI: https://doi.org/10.1124/dmd.119.089813

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Research ArticleArticle

CYP3A4 Time-Dependent Inhibition by Cysteine-Targeting Electrophiles

John T. Barr, Zhican Wang, Xiaoshan Min, Henry J. Wienkers, Brooke M. Rock, Dan A. Rock and Larry C. Wienkers
Drug Metabolism and Disposition June 1, 2020, 48 (6) 508-514; DOI: https://doi.org/10.1124/dmd.119.089813
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