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Drug Metabolism & Disposition

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Table of Contents

August 01, 2020; Volume 48,Issue 8

Articles

  • You have access
    Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?
    John T. Barr, Thuy B. Tran, Brooke M. Rock, Jan L. Wahlstrom and Upendra P. Dahal
    Drug Metabolism and Disposition August 2020, 48 (8) 613-621; DOI: https://doi.org/10.1124/dmd.120.090621
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    OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP
    Yuchen Zhang, Melissa Ruggiero and Bruno Hagenbuch
    Drug Metabolism and Disposition August 2020, 48 (8) 622-630; DOI: https://doi.org/10.1124/dmd.119.089847
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    The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species
    Marilyn N. Martinez, Jonathan Greene, Leslie Kenna, Lindsey Kissell and Matt Kuhn
    Drug Metabolism and Disposition August 2020, 48 (8) 631-644; DOI: https://doi.org/10.1124/dmd.120.090704
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    Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism
    Alexander M. Horspool, Ting Wang, Young-Sun Scaringella, Mitchell E. Taub and Tom S. Chan
    Drug Metabolism and Disposition August 2020, 48 (8) 645-654; DOI: https://doi.org/10.1124/dmd.120.090696
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    NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition
    Mika Kosaka, Donglu Zhang, Simon Wong and Zhengyin Yan
    Drug Metabolism and Disposition August 2020, 48 (8) 655-661; DOI: https://doi.org/10.1124/dmd.120.090878
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    Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations
    Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia and Ke Lan
    Drug Metabolism and Disposition August 2020, 48 (8) 662-672; DOI: https://doi.org/10.1124/dmd.120.000011
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    Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice
    Takashi Ashino, Masayuki Yamamoto and Satoshi Numazawa
    Drug Metabolism and Disposition August 2020, 48 (8) 673-680; DOI: https://doi.org/10.1124/dmd.120.000010
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    Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice
    Haiman Xu, Min Chen, Fangjun Yu, Tianpeng Zhang and Baojian Wu
    Drug Metabolism and Disposition August 2020, 48 (8) 681-689; DOI: https://doi.org/10.1124/dmd.120.000030
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    Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture
    Tom S. Chan, Young-Sun Scaringella, Klairynne Raymond and Mitchell E. Taub
    Drug Metabolism and Disposition August 2020, 48 (8) 690-697; DOI: https://doi.org/10.1124/dmd.120.090951
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    Excretion, Mass Balance, and Metabolism of [14C]LY3202626 in Humans: An Interplay of Microbial Reduction, Reabsorption, and Aldehyde Oxidase Oxidation That Leads to an Extended Excretion Profile
    Kishore Katyayan, Ping Yi, Scott Monk and Kenneth Cassidy
    Drug Metabolism and Disposition August 2020, 48 (8) 698-707; DOI: https://doi.org/10.1124/dmd.120.000009
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    Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy
    Lyrialle W. Han, Lu Wang, Yuanyuan Shi, Joseph L. Dempsey, Olesya V. Pershutkina, Moumita Dutta, Theo K. Bammler, Julia Y. Cui and Qingcheng Mao
    Drug Metabolism and Disposition August 2020, 48 (8) 708-722; DOI: https://doi.org/10.1124/dmd.120.000039
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    Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition
    Xiaomei Gu, Lifei Wang, Jinping Gan, R. Marcus Fancher, Yuan Tian, Yang Hong, Yurong Lai, Michael Sinz and Hong Shen
    Drug Metabolism and Disposition August 2020, 48 (8) 724-734; DOI: https://doi.org/10.1124/dmd.120.090670

Erratum

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    Correction to “Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers”
    Drug Metabolism and Disposition August 2020, 48 (8) 723; DOI: https://doi.org/10.1124/dmd.120.000141
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Drug Metabolism and Disposition: 48 (8)
Drug Metabolism and Disposition
Vol. 48, Issue 8
1 Aug 2020
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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