Table of Contents

Articles

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  Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

  John T. Barr, Thuy B. Tran, Brooke M. Rock, Jan L. Wahlstrom and Upendra P. Dahal

  Drug Metabolism and Disposition August 2020, 48 (8) 613-621; DOI: https://doi.org/10.1124/dmd.120.090621
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  OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP

  Yuchen Zhang, Melissa Ruggiero and Bruno Hagenbuch

  Drug Metabolism and Disposition August 2020, 48 (8) 622-630; DOI: https://doi.org/10.1124/dmd.119.089847
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  The Impact of Infection and Inflammation on Drug Metabolism, Active Transport, and Systemic Drug Concentrations in Veterinary Species

  Marilyn N. Martinez, Jonathan Greene, Leslie Kenna, Lindsey Kissell and Matt Kuhn

  Drug Metabolism and Disposition August 2020, 48 (8) 631-644; DOI: https://doi.org/10.1124/dmd.120.090704
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  Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism

  Alexander M. Horspool, Ting Wang, Young-Sun Scaringella, Mitchell E. Taub and Tom S. Chan

  Drug Metabolism and Disposition August 2020, 48 (8) 645-654; DOI: https://doi.org/10.1124/dmd.120.090696
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  NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition

  Mika Kosaka, Donglu Zhang, Simon Wong and Zhengyin Yan

  Drug Metabolism and Disposition August 2020, 48 (8) 655-661; DOI: https://doi.org/10.1124/dmd.120.090878
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  Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations

  Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia and Ke Lan

  Drug Metabolism and Disposition August 2020, 48 (8) 662-672; DOI: https://doi.org/10.1124/dmd.120.000011
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  Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice

  Takashi Ashino, Masayuki Yamamoto and Satoshi Numazawa

  Drug Metabolism and Disposition August 2020, 48 (8) 673-680; DOI: https://doi.org/10.1124/dmd.120.000010
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  Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice

  Haiman Xu, Min Chen, Fangjun Yu, Tianpeng Zhang and Baojian Wu

  Drug Metabolism and Disposition August 2020, 48 (8) 681-689; DOI: https://doi.org/10.1124/dmd.120.000030
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  Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture

  Tom S. Chan, Young-Sun Scaringella, Klairynne Raymond and Mitchell E. Taub

  Drug Metabolism and Disposition August 2020, 48 (8) 690-697; DOI: https://doi.org/10.1124/dmd.120.090951
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  Excretion, Mass Balance, and Metabolism of [¹⁴C]LY3202626 in Humans: An Interplay of Microbial Reduction, Reabsorption, and Aldehyde Oxidase Oxidation That Leads to an Extended Excretion Profile

  Kishore Katyayan, Ping Yi, Scott Monk and Kenneth Cassidy

  Drug Metabolism and Disposition August 2020, 48 (8) 698-707; DOI: https://doi.org/10.1124/dmd.120.000009
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  Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy

  Lyrialle W. Han, Lu Wang, Yuanyuan Shi, Joseph L. Dempsey, Olesya V. Pershutkina, Moumita Dutta, Theo K. Bammler, Julia Y. Cui and Qingcheng Mao

  Drug Metabolism and Disposition August 2020, 48 (8) 708-722; DOI: https://doi.org/10.1124/dmd.120.000039
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  Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition

  Xiaomei Gu, Lifei Wang, Jinping Gan, R. Marcus Fancher, Yuan Tian, Yang Hong, Yurong Lai, Michael Sinz and Hong Shen

  Drug Metabolism and Disposition August 2020, 48 (8) 724-734; DOI: https://doi.org/10.1124/dmd.120.090670