Amiodarone | 645.3 | Acidic | 6.6 | 5.9 | Hepatic metabolism (CYP3A and 2C8) and biliary excretion of metabolitesb |
Captopril | 217.3 | Zwitterion | 3.7, 9.8 | −2.8 | Urinary excretion of unchanged drug (40%–50%) + disulfide dimer or cysteine conjugatec |
Chlorpromazine | 318.9 | Basic | 9.3 | 3.2 | Metabolism (oxidative) and urinary excretion of metabolites (43%–65%)d |
Dexamethasone | 392.5 | Neutral | — | −4.6 | Hepatic metabolism (CYP3A) and urinary excretion of metabolites (65%)e |
Fluvastatin | 411.5 | Acidic | 4.5 | −2.2 | Hepatic metabolism (CYP2C9) and biliary elimination (∼90%)f |
Levofloxacin | 361.4 | Zwitterion | 6.2, 8.7 | −0.39 | Urinary excretion of unchanged drug (∼87%)g |
Naproxen | 230.3 | Acidic | 4.2 | 0.35 | Urinary excretion of glucuronide metabolite (66%–92%)h |
Propranolol | 259.4 | Basic | 9.4 | 0.79 | Metabolism (oxidative - CYP1A2 and 2D6 and glucuronidation)i |