Research ArticleArticle
Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations
Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia and Ke Lan
Drug Metabolism and Disposition August 2020, 48 (8) 662-672; DOI: https://doi.org/10.1124/dmd.120.000011
Wen-Xia Wang
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Li Chen
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Guo-Yu Wang
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Jin-Ling Zhang
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Xian-Wen Tan
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Qiu-Hong Lin
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Yu-Jie Chen
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Jian Zhang
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Ping-Ping Zhu
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Jia Miao
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Ming-Ming Su
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Chang-Xiao Liu
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Wei Jia
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Ke Lan
Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
Article Information
vol. 48 no. 8 662-672
PubMed
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History
- Received March 13, 2020
- Accepted April 30, 2020
- Published online July 15, 2020.
Article Versions
- Earlier version (June 4, 2020 - 05:17).
- You are viewing the most recent version of this article.
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Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Wen-Xia Wang1,
- Li Chen1,
- Guo-Yu Wang,
- Jin-Ling Zhang,
- Xian-Wen Tan,
- Qiu-Hong Lin,
- Yu-Jie Chen,
- Jian Zhang,
- Ping-Ping Zhu,
- Jia Miao,
- Ming-Ming Su,
- Chang-Xiao Liu,
- Wei Jia, and
- Ke Lan
- Key laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy (W.-X.W., X.-W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.), Evidence-Based Pharmacy Center, Department of Pharmacy, West China Second University Hospital (L.C.), Labor And Delivery Room, West China Second University Hospital, (G.-Y.W., J.-L.Z.), Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, (L.C., G.-Y.W., J.-L.Z.), and Institute of Clinical Pharmacology, West China Hospital, (J.M.), Sichuan University, Chengdu, China; Metabolomics Shared Resource, University of Hawaii Cancer Center, Honolulu, Hawaii (M.-M.S., W.J.); State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China (C.-X.L.); and Chengdu Health-Balance Medical Technology Co., Ltd., Chengdu, China (W.-X.W., X.W.T., Q.-H.L., Y.-J.C., J.Z., P.-P.Z., K.L.)
- Address correspondence to:
Dr. Ke Lan, West China School of Pharmacy, Sichuan University, No.17 People’s South Road, Chengdu 610041, China. E-mail: lanwoco{at}scu.edu.cn
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In this issue
Research ArticleArticle
Oxidative Metabolism of Primary Bile Acids in Newborns
Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia and Ke Lan
Drug Metabolism and Disposition August 1, 2020, 48 (8) 662-672; DOI: https://doi.org/10.1124/dmd.120.000011
Research ArticleArticle
Oxidative Metabolism of Primary Bile Acids in Newborns
Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia and Ke Lan
Drug Metabolism and Disposition August 1, 2020, 48 (8) 662-672; DOI: https://doi.org/10.1124/dmd.120.000011
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