Drug Metabolism and Disposition: 49 (1)

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About the cover: In silico prediction of intracellular drug distribution to lysosomes in vitro and its incorporation into whole body PBPK modeling. See the article by Schmitt et al. (dx.doi.org/10.1124/dmd.120.000161).

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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