Advertisement

Index by author

January 01, 2021; Volume 49,Issue 1

A

  1. Achour, Brahim

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  2. Al-Majdoub, Zubida M.

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  3. Aluri, Jagadeesh

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

  4. Asakura, Shoji

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

B

  1. Barber, Jill

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  2. Beuckmann, Carsten T.

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

  3. Bi, Yi-an

    1. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
      Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
      Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

C

  1. Chen, Liangfu

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Chen, Shujuan

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  3. Clench, Malcolm R.

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  4. Corton, J. Christopher

    1. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181

  5. Couto, Narciso

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  6. Cui, Julia Yue

    1. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181

D

  1. Dallas, Shannon

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Deguchi, Yoshiharu

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  3. Ding, Xinxin

    1. Editorial
      Xinxin Ding
      Drug Metabolism and Disposition January 2021, 49 (1) 1-2; DOI: https://doi.org/10.1124/dmd.120.000298

E

  1. Einolf, Heidi J.

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Endo, Hiromi

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  3. Enomoto, Tsuyoshi

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

F

  1. Fricker, Gert

    1. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
      Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161

  2. Fung, Conrad

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

G

  1. Goosen, Theunis C.

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Guo, Ying

    1. Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice
      Chong Ma, Ying Guo and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 62-71; DOI: https://doi.org/10.1124/dmd.120.000166

H

  1. Hamada, Makoto

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  2. Hariparsad, Niresh

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  3. Higuchi, Kei

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

I

  1. Ishida, Tomomi

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

J

  1. Jones, Barry

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Jonker, Johan W.

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

K

  1. Kameyama, Takaaki

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

  2. Karunakaran, Esther

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  3. Kato, Sota

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  4. Kawabata, Kenji

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  5. Klaassen, Curtis D.

    1. Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice
      Chong Ma, Ying Guo and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 62-71; DOI: https://doi.org/10.1124/dmd.120.000166
    2. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181

  6. Kurimori, Ko

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  7. Kurosawa, Toshiki

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  8. Kusano, Kazutomi

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

  9. Kusuhara, Hiroyuki

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115
    2. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

L

  1. Lienau, Philip

    1. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
      Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161

  2. Liu, Jie

    1. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181

  3. Liu, Xiaohui

    1. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
      Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161

  4. Lu, Yuan-Fu

    1. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
      Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181

M

  1. Ma, Chong

    1. Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice
      Chong Ma, Ying Guo and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2021, 49 (1) 62-71; DOI: https://doi.org/10.1124/dmd.120.000166

  2. Maeda, Kazuya

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  3. Mennillo, Elvira

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  4. Michiba, Kazuyoshi

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  5. Mizuno, Tadahaya

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  6. Mochizuki, Tatsuki

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

N

  1. Newton, Jillian R.A.

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  2. Nishiyama, Hiroyuki

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  3. Nozaki, Yoshitane

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

O

  1. Oda, Tatsuya

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

P

  1. Palamanda, Jairam

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

R

  1. Ramsden, Diane

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  2. Reichel, Andreas

    1. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
      Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161

  3. Rodrigues, A. David

    1. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
      Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
      Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

  4. Rostami-Hodjegan, Amin

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  5. Russo, Cristina

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  6. Ryu, Sangwoo

    1. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
      Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
      Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

S

  1. Schmitt, Maximilian V.

    1. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
      Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
      Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161

  2. Shimomura, Osamu

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  3. Sidaway, James

    1. Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model
      Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber
      Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

  4. Siu, Y. Amy

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

  5. Suzuki, Michiyuki

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

T

  1. Tada, Mika

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  2. Takano, Hiroki

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  3. Takeuchi, Tomoyo

    1. Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum
      Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 84-93; DOI: https://doi.org/10.1124/dmd.120.000138

  4. Tega, Yuma

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  5. Tess, David A.

    1. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
      Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
      Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

  6. Tukey, Robert H.

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  7. Tweedie, Donald

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

U

  1. Ueno, Takashi

    1. Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites
      Takashi Ueno, Tomomi Ishida, Jagadeesh Aluri, Michiyuki Suzuki, Carsten T. Beuckmann, Takaaki Kameyama, Shoji Asakura and Kazutomi Kusano
      Drug Metabolism and Disposition January 2021, 49 (1) 31-38; DOI: https://doi.org/10.1124/dmd.120.000229

V

  1. van der Schoor, Lori W.E.

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  2. Varma, Manthena V. S.

    1. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
      Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma
      Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

W

  1. Weber, André A.

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  2. Wong, Simon G.

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

Y

  1. Yamaguchi, Jun-ichi

    1. Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
      Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo
      Drug Metabolism and Disposition January 2021, 49 (1) 20-30; DOI: https://doi.org/10.1124/dmd.120.000124

  2. Yamaguchi, Tomoko

    1. Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier
      Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi and Hiroyuki Kusuhara
      Drug Metabolism and Disposition January 2021, 49 (1) 3-11; DOI: https://doi.org/10.1124/dmd.120.000115

  3. Yang, Xiaojing

    1. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation
      André A. Weber, Elvira Mennillo, Xiaojing Yang, Lori W.E. van der Schoor, Johan W. Jonker, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2021, 49 (1) 12-19; DOI: https://doi.org/10.1124/dmd.120.000240

  4. Yates, Phillip D.

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

Z

  1. Zhang, George

    1. Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
      Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates
      Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055
Back to top

In this issue