Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model

Narciso Couto; Jillian R.A. Newton; Cristina Russo; Esther Karunakaran; Brahim Achour; Zubida M. Al-Majdoub; James Sidaway; Amin Rostami-Hodjegan; Malcolm R. Clench; Jill Barber

doi:10.1124/dmd.120.000168

Research ArticleArticle

Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model

Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber

Drug Metabolism and Disposition January 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

Narciso Couto

Department of Chemical and Biological Engineering (N.C., E.K.) and Sheffield Collaboratorium for Antimicrobial Resistance and Biofilms (SCARAB) (N.C., E.K.), University of Sheffield, Sheffield, United Kingdom; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., B.A., Z.M.A.-M., A.R.-H., J.B.); Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom (J.R.A.N., C.R., M.R.C.); Phenotox Ltd., Bollington, United Kingdom (J.S.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (A.R.-H.)

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Jillian R.A. Newton

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Cristina Russo

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Esther Karunakaran

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Brahim Achour

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Zubida M. Al-Majdoub

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James Sidaway

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Amin Rostami-Hodjegan

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Malcolm R. Clench

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Jill Barber

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Drug Metabolism and Disposition

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Research ArticleArticle

XMEs and Transporters in Human Skin and an Equivalent Model

Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber

Drug Metabolism and Disposition January 1, 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

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Research ArticleArticle

XMEs and Transporters in Human Skin and an Equivalent Model

Narciso Couto, Jillian R.A. Newton, Cristina Russo, Esther Karunakaran, Brahim Achour, Zubida M. Al-Majdoub, James Sidaway, Amin Rostami-Hodjegan, Malcolm R. Clench and Jill Barber

Drug Metabolism and Disposition January 1, 2021, 49 (1) 39-52; DOI: https://doi.org/10.1124/dmd.120.000168

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