Research ArticleArticle
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
Drug Metabolism and Disposition January 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161
Maximilian V. Schmitt
Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)
Andreas Reichel
Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)
Xiaohui Liu
Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)
Gert Fricker
Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)
Philip Lienau
Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., A.R., P.L.); School of Life Sciences, Tsinghua University, Beijing, China (X.L.); and Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)

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Research ArticleArticle
Drug Tissue Distribution Incorporating Lysosomal Trapping
Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau
Drug Metabolism and Disposition January 1, 2021, 49 (1) 53-61; DOI: https://doi.org/10.1124/dmd.120.000161
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