Table of Contents

Articles

• Open Access

  Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane

  Irina Teslenko, Christy J.W. Watson, Zuping Xia, Gang Chen and Philip Lazarus

  Drug Metabolism and Disposition December 2021, 49 (12) 1047-1055; DOI: https://doi.org/10.1124/dmd.121.000635
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  HLM-beads: Rapid Assessment of Nonspecific Binding to Human Liver Microsomes Using Magnetizable Beads

  Ting Wang, Andrea Whitcher-Johnstone, Monica Keith-Luzzi and Tom S. Chan

  Drug Metabolism and Disposition December 2021, 49 (12) 1056-1062; DOI: https://doi.org/10.1124/dmd.121.000575
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  Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition

  Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

  Drug Metabolism and Disposition December 2021, 49 (12) 1063-1069; DOI: https://doi.org/10.1124/dmd.121.000486
• Open Access

  Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics

  Márton Kiss, Richard Mbasu, Johan Nicolaï, Karin Barnouin, Apoorva Kotian, Miriam G. Mooij, Nico Kist, Rene M. H. Wijnen, Anna-Lena Ungell, Paul Cutler, Frans G. M. Russel and Saskia N. de Wildt

  Drug Metabolism and Disposition December 2021, 49 (12) 1038-1046; DOI: https://doi.org/10.1124/dmd.121.000559
• Open Access

  Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

  Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus

  Drug Metabolism and Disposition December 2021, 49 (12) 1070-1080; DOI: https://doi.org/10.1124/dmd.121.000442
• Open Access

  Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites

  Shamema Nasrin, Christy J. W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

  Drug Metabolism and Disposition December 2021, 49 (12) 1081-1089; DOI: https://doi.org/10.1124/dmd.121.000530
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  Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 1. Theoretical Considerations

  Zeyuan Wang, Erickson M. Paragas, Swati Nagar and Ken Korzekwa

  Drug Metabolism and Disposition December 2021, 49 (12) 1090-1099; DOI: https://doi.org/10.1124/dmd.121.000553
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  Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 2. Modeling of Experimental Data

  Erickson M. Paragas, Zeyuan Wang, Ken Korzekwa and Swati Nagar

  Drug Metabolism and Disposition December 2021, 49 (12) 1100-1108; DOI: https://doi.org/10.1124/dmd.121.000554
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  Open Access

  Pharmacokinetics and ADME Characterization of Intravenous and Oral [¹⁴C]-Linerixibat in Healthy Male Volunteers

  Maciej J. Zamek-Gliszczynski, David Kenworthy, David A. Bershas, Mitesh Sanghvi, Adrian I. Pereira, Jennypher Mudunuru, Lee Crossman, Jill L. Pirhalla, Karl M. Thorpe, Jeremy M.T.J. Dennison, Megan M. McLaughlin, Matthew Allinder, Brandon Swift, Robin L. O’Connor-Semmes and Graeme C. Young

  Drug Metabolism and Disposition December 2021, 49 (12) 1109-1117; DOI: https://doi.org/10.1124/dmd.121.000595