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Drug Metabolism & Disposition

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Table of Contents

February 01, 2021; Volume 49,Issue 2

Articles

  • You have access
    In Vitro Metabolism of Slowly Cleared G Protein–Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism
    Amin Kamel, Steve Bowlin, Natalie Hosea, Dimitrios Arkilo and Antonio Laurenza
    Drug Metabolism and Disposition February 2021, 49 (2) 121-132; DOI: https://doi.org/10.1124/dmd.120.000246
  • Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
    Open Access
    Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
    Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller
    Drug Metabolism and Disposition February 2021, 49 (2) 133-141; DOI: https://doi.org/10.1124/dmd.120.000254
  • You have access
    Use of Intravenous Infusion Study Design to Simultaneously Determine Brain Penetration and Systemic Pharmacokinetic Parameters in Rats
    Keumhan Noh, Alicia Pietrasiewicz, Xingrong Liu and Cong Wei
    Drug Metabolism and Disposition February 2021, 49 (2) 142-151; DOI: https://doi.org/10.1124/dmd.120.000242
  • Open Access
    Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors
    Asami Saito, Naoki Ishiguro, Masahito Takatani, Bojan Bister and Hiroyuki Kusuhara
    Drug Metabolism and Disposition February 2021, 49 (2) 152-158; DOI: https://doi.org/10.1124/dmd.120.000136
  • You have access
    Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
    Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E.C.A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward and Jashvant D. Unadkat
    Drug Metabolism and Disposition February 2021, 49 (2) 159-168; DOI: https://doi.org/10.1124/dmd.120.000204
  • Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
    Open Access
    Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
    Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber
    Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202
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Drug Metabolism and Disposition: 49 (2)
Drug Metabolism and Disposition
Vol. 49, Issue 2
1 Feb 2021
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