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Tryptophan-75 Is a Low-Energy Channel-Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6

Kevin D. McCarty, Samuel A. Ratliff, Kyle A. Furge and Laura Lowe Furge
Drug Metabolism and Disposition March 2021, 49 (3) 179-187; DOI: https://doi.org/10.1124/dmd.120.000274

Article Information

vol. 49 no. 3 179-187
DOI 
https://doi.org/10.1124/dmd.120.000274
PubMed 
33376147
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 5, 2020
  • Accepted December 21, 2020
  • Published online February 9, 2021.

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Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kevin D. McCarty,
  2. Samuel A. Ratliff,
  3. Kyle A. Furge, and
  4. Laura Lowe Furge
  1. Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan
  1. Address correspondence to:
    Laura Lowe Furge, Department of Chemistry, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006. E-mail: Laura.Furge{at}kzoo.edu
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Feb 202148243750
Mar 202122228742
Apr 20211791015

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Trp75 and Ligand Egress/Access in CYP2D6

Kevin D. McCarty, Samuel A. Ratliff, Kyle A. Furge and Laura Lowe Furge
Drug Metabolism and Disposition March 1, 2021, 49 (3) 179-187; DOI: https://doi.org/10.1124/dmd.120.000274
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