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Research ArticleArticle

Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib

Dasean T. Nardone-White, Jennifer E. Bissada, Arsany A. Abouda and Klarissa D. Jackson
Drug Metabolism and Disposition March 2021, 49 (3) 233-244; DOI: https://doi.org/10.1124/dmd.120.000236
Dasean T. Nardone-White
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)
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Jennifer E. Bissada
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)
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Arsany A. Abouda
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)
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Klarissa D. Jackson
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (D.T.N.-W., K.D.J.) and Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee (J.E.B., A.A.A.)
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Drug Metabolism and Disposition: 49 (3)
Drug Metabolism and Disposition
Vol. 49, Issue 3
1 Mar 2021
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Research ArticleArticle

Glucuronidation of Debenzylated Lapatinib by UGT1A1

Dasean T. Nardone-White, Jennifer E. Bissada, Arsany A. Abouda and Klarissa D. Jackson
Drug Metabolism and Disposition March 1, 2021, 49 (3) 233-244; DOI: https://doi.org/10.1124/dmd.120.000236

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Research ArticleArticle

Glucuronidation of Debenzylated Lapatinib by UGT1A1

Dasean T. Nardone-White, Jennifer E. Bissada, Arsany A. Abouda and Klarissa D. Jackson
Drug Metabolism and Disposition March 1, 2021, 49 (3) 233-244; DOI: https://doi.org/10.1124/dmd.120.000236
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