Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity

Keiya Hirosawa; Tatsuki Fukami; Kiyomichi Tashiro; Yoshiyuki Sakai; Fumiya Kisui; Masataka Nakano; Miki Nakajima

doi:10.1124/dmd.120.000295

Research ArticleArticle

Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity

Keiya Hirosawa, Tatsuki Fukami, Kiyomichi Tashiro, Yoshiyuki Sakai, Fumiya Kisui, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition April 2021, 49 (4) 322-329; DOI: https://doi.org/10.1124/dmd.120.000295

Keiya Hirosawa

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan (K.H., T.F., K.T., Y.S., F.K., Ma.N., Mi.N.); and WPI Nano Life Science Institute, Kakuma-machi, Kanazawa, Japan (T.F., Ma.N., Mi.N.)

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Tatsuki Fukami

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Kiyomichi Tashiro

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Yoshiyuki Sakai

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Fumiya Kisui

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Masataka Nakano

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Miki Nakajima

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Drug Metabolism and Disposition

Vol. 49, Issue 4

1 Apr 2021

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