Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

Frederick Hsu; Yi-Chen Chen; Fabio Broccatelli

doi:10.1124/dmd.120.000337

Research ArticleArticle

Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli

Drug Metabolism and Disposition April 2021, 49 (4) 330-336; DOI: https://doi.org/10.1124/dmd.120.000337

Frederick Hsu

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California

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Yi-Chen Chen

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California

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Fabio Broccatelli

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California

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Drug Metabolism and Disposition

Vol. 49, Issue 4

1 Apr 2021

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Research ArticleArticle

Predicting Volume of Distribution from In Vitro Parameters

Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli

Drug Metabolism and Disposition April 1, 2021, 49 (4) 330-336; DOI: https://doi.org/10.1124/dmd.120.000337

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Research ArticleArticle

Predicting Volume of Distribution from In Vitro Parameters

Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli

Drug Metabolism and Disposition April 1, 2021, 49 (4) 330-336; DOI: https://doi.org/10.1124/dmd.120.000337

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Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

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Predicting Volume of Distribution from In Vitro Parameters

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