Table of Contents

Articles

• Open Access

  Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans

  Päivi Taavitsainen, Olaf Prien, Marja Kähkönen, Michael Niehues, Timo Korjamo, Karsten Denner, Pirjo Nykänen, Annamari Vuorela, Natalia A. Jungmann, Clemens-Jeremias von Bühler, Mikko Koskinen, Christian Zurth and Hille Gieschen

  Drug Metabolism and Disposition June 2021, 49 (6) 420-433; DOI: https://doi.org/10.1124/dmd.120.000309
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  Dual Action of Acidic Microenvironment on the Enrichment of the Active Metabolite of Disulfiram in Tumor Tissues

  Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu and Xiaoyan Chen

  Drug Metabolism and Disposition June 2021, 49 (6) 434-441; DOI: https://doi.org/10.1124/dmd.120.000317
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  Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants

  Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

  Drug Metabolism and Disposition June 2021, 49 (6) 442-450; DOI: https://doi.org/10.1124/dmd.121.000356
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  Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses

  Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood

  Drug Metabolism and Disposition June 2021, 49 (6) 451-458; DOI: https://doi.org/10.1124/dmd.120.000330
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  Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone A

  Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

  Drug Metabolism and Disposition June 2021, 49 (6) 459-469; DOI: https://doi.org/10.1124/dmd.120.000325
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  In Vitro–to–In Vivo Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach

  Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

  Drug Metabolism and Disposition June 2021, 49 (6) 470-478; DOI: https://doi.org/10.1124/dmd.121.000367