Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplemental Table 1 - Incubation conditions for CYP-mediated reactions.
Supplemental Table 2 - Analytical conditions for quantification of the internal standards (IS) and the metabolites of CYP probe substrates.
Supplemental Table 2 - Incubation conditions for enzyme inhibition kinetics.
Supplemental Table 4 - IC50 values of MOA against seven CYPs and ketoconazole against CYP3A in human liver microsomes, with 0 min or 30 min pre-incubation.
Supplemental Table 5 - The interactions between MOA and CYP1A2, CYP2D6 or CYP2E1 utilizing docking simulations.
Supplemental Figure 1 - The inhibitory effects of MOA on eight major CYPs in HLMs.
Supplemental Figure 2 - Mass spectrometric characterization of MOA.
Supplemental Figure 3 - 2D representation of the interactions between MOA and the residuals in the active site of CYP1A2.
Supplemental Figure 4 - 2D representation of the interactions between MOA and the residuals in the active site of CYP2D6.
Supplemental Figure 5 - 2D representation of the interactions between MOA and the residuals in the active site of CYP2E1.
- Supplemental Data -