Fig. 1. Blood concentration-time profile in Tg-Composite animals after oral administration of (A) rifampin at 3, 10, 30, and 100 mg/kg, (B) efavirenz at 5, 15, 50, and 250 mg/kg, and (C) pioglitazone at 1, 5, 50, and 200 mg/kg. Starting with the lowest dose, the first dose is shown as inverted orange triangle, the second dose is shown as green circle, the third dose is shown as blue triangle, and the highest dose is shown as purple square. Data are presented as mean ± S.D. (N = 4).