Table of Contents

Articles

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  Investigation into MAO B–Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B

  April Bai, Veerabahu Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni and Deepak Dalvie

  Drug Metabolism and Disposition August 2021, 49 (8) 601-609; DOI: https://doi.org/10.1124/dmd.121.000447
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  Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes

  Eman El-Khateeb, Zubida M. Al-Majdoub, Amin Rostami-Hodjegan, Jill Barber and Brahim Achour

  Drug Metabolism and Disposition August 2021, 49 (8) 610-618; DOI: https://doi.org/10.1124/dmd.121.000484
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  Pharmacokinetics, Disposition, and Biotransformation of [¹⁴C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose

  Ashit Trivedi, Jan Wahlstrom, Mia Mackowski, Sandeep Dutta and Edward Lee

  Drug Metabolism and Disposition August 2021, 49 (8) 619-628; DOI: https://doi.org/10.1124/dmd.121.000444
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  BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity

  Xia Wen, Danielle Kozlosky, Ranran Zhang, Cathleen Doherty, Brian Buckley, Emily Barrett and Lauren M. Aleksunes

  Drug Metabolism and Disposition August 2021, 49 (8) 629-637; DOI: https://doi.org/10.1124/dmd.121.000446
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  Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9

  Dongyi Sun, Jian Lu, Yuanjin Zhang, Jie Liu, Zongjun Liu, Bingyi Yao, Yuanqing Guo and Xin Wang

  Drug Metabolism and Disposition August 2021, 49 (8) 638-647; DOI: https://doi.org/10.1124/dmd.121.000403
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  Passive Influx and Ion Trapping Are More Relevant to the Cellular Accumulation of Highly Permeable Low-Molecular-Weight Acidic Drugs than Is Organic Anion Transporter 2

  Dallas Bednarczyk

  Drug Metabolism and Disposition August 2021, 49 (8) 648-657; DOI: https://doi.org/10.1124/dmd.121.000425
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  Open Access

  Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins

  Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi

  Drug Metabolism and Disposition August 2021, 49 (8) 658-667; DOI: https://doi.org/10.1124/dmd.121.000406
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  Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells

  Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke and Carl Petersson

  Drug Metabolism and Disposition August 2021, 49 (8) 668-678; DOI: https://doi.org/10.1124/dmd.120.000333
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  Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation

  Md Masud Parvez, Abdul Basit, Parth B. Jariwala, Zsuzsanna Gáborik, Emese Kis, Scott Heyward, Matthew R. Redinbo and Bhagwat Prasad

  Drug Metabolism and Disposition August 2021, 49 (8) 683-693; DOI: https://doi.org/10.1124/dmd.121.000476
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  3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans

  Monica L. Vermillion Maier, Lisbeth K. Siddens, Sandra L. Uesugi, Jaewoo Choi, Scott W. Leonard, Jamie M. Pennington, Susan C. Tilton, Jordan N. Smith, Emily Ho, H.H. Sherry Chow, Bach D. Nguyen, Siva K. Kolluri and David E. Williams

  Drug Metabolism and Disposition August 2021, 49 (8) 694-705; DOI: https://doi.org/10.1124/dmd.120.000346
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  Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins

  Liberta Cuko, Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Asmita Pant, John K. Fallon, Elizabeth M. Wilson, Nicholas J. Peraino, Judy A. Westrick, Philip C. Smith and Thomas A. Kocarek

  Drug Metabolism and Disposition August 2021, 49 (8) 706-717; DOI: https://doi.org/10.1124/dmd.120.000341