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Drug Metabolism & Disposition

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Table of Contents

August 01, 2021; Volume 49,Issue 8

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    Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug
    Zahir Hussain, Junjie Zhu and Xiaochao Ma
    Drug Metabolism and Disposition August 2021, 49 (8) 679-682; DOI: https://doi.org/10.1124/dmd.121.000389

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    Investigation into MAO B–Mediated Formation of CC112273, a Major Circulating Metabolite of Ozanimod, in Humans and Preclinical Species: Stereospecific Oxidative Deamination of (S)-Enantiomer of Indaneamine (RP101075) by MAO B
    April Bai, Veerabahu Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni and Deepak Dalvie
    Drug Metabolism and Disposition August 2021, 49 (8) 601-609; DOI: https://doi.org/10.1124/dmd.121.000447
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    Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes
    Eman El-Khateeb, Zubida M. Al-Majdoub, Amin Rostami-Hodjegan, Jill Barber and Brahim Achour
    Drug Metabolism and Disposition August 2021, 49 (8) 610-618; DOI: https://doi.org/10.1124/dmd.121.000484
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    Pharmacokinetics, Disposition, and Biotransformation of [14C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose
    Ashit Trivedi, Jan Wahlstrom, Mia Mackowski, Sandeep Dutta and Edward Lee
    Drug Metabolism and Disposition August 2021, 49 (8) 619-628; DOI: https://doi.org/10.1124/dmd.121.000444
  • BCRP/<em>ABCG2</em> Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity
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    BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity
    Xia Wen, Danielle Kozlosky, Ranran Zhang, Cathleen Doherty, Brian Buckley, Emily Barrett and Lauren M. Aleksunes
    Drug Metabolism and Disposition August 2021, 49 (8) 629-637; DOI: https://doi.org/10.1124/dmd.121.000446
  • Characterization of a Novel <em>CYP1A2</em> Knockout Rat Model Constructed by CRISPR/Cas9
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    Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9
    Dongyi Sun, Jian Lu, Yuanjin Zhang, Jie Liu, Zongjun Liu, Bingyi Yao, Yuanqing Guo and Xin Wang
    Drug Metabolism and Disposition August 2021, 49 (8) 638-647; DOI: https://doi.org/10.1124/dmd.121.000403
  • Passive Influx and Ion Trapping Are More Relevant to the Cellular Accumulation of Highly Permeable Low-Molecular-Weight Acidic Drugs than Is Organic Anion Transporter 2
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    Passive Influx and Ion Trapping Are More Relevant to the Cellular Accumulation of Highly Permeable Low-Molecular-Weight Acidic Drugs than Is Organic Anion Transporter 2
    Dallas Bednarczyk
    Drug Metabolism and Disposition August 2021, 49 (8) 648-657; DOI: https://doi.org/10.1124/dmd.121.000425
  • Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins
    Open Access
    Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins
    Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi
    Drug Metabolism and Disposition August 2021, 49 (8) 658-667; DOI: https://doi.org/10.1124/dmd.121.000406
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    Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells
    Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke and Carl Petersson
    Drug Metabolism and Disposition August 2021, 49 (8) 668-678; DOI: https://doi.org/10.1124/dmd.120.000333
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    Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation
    Md Masud Parvez, Abdul Basit, Parth B. Jariwala, Zsuzsanna Gáborik, Emese Kis, Scott Heyward, Matthew R. Redinbo and Bhagwat Prasad
    Drug Metabolism and Disposition August 2021, 49 (8) 683-693; DOI: https://doi.org/10.1124/dmd.121.000476
  • 3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
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    3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
    Monica L. Vermillion Maier, Lisbeth K. Siddens, Sandra L. Uesugi, Jaewoo Choi, Scott W. Leonard, Jamie M. Pennington, Susan C. Tilton, Jordan N. Smith, Emily Ho, H.H. Sherry Chow, Bach D. Nguyen, Siva K. Kolluri and David E. Williams
    Drug Metabolism and Disposition August 2021, 49 (8) 694-705; DOI: https://doi.org/10.1124/dmd.120.000346
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    Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins
    Liberta Cuko, Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Asmita Pant, John K. Fallon, Elizabeth M. Wilson, Nicholas J. Peraino, Judy A. Westrick, Philip C. Smith and Thomas A. Kocarek
    Drug Metabolism and Disposition August 2021, 49 (8) 706-717; DOI: https://doi.org/10.1124/dmd.120.000341
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Drug Metabolism and Disposition: 49 (8)
Drug Metabolism and Disposition
Vol. 49, Issue 8
1 Aug 2021
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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