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Drug Metabolism & Disposition

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Table of Contents

September 01, 2021; Volume 49,Issue 9

Articles

  • You have access
    Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans
    Shiori Honda, Tatsuki Fukami, Keiya Hirosawa, Takuya Tsujiguchi, Yongjie Zhang, Masataka Nakano, Shotaro Uehara, Yasuhiro Uno, Hiroshi Yamazaki and Miki Nakajima
    Drug Metabolism and Disposition September 2021, 49 (9) 718-728; DOI: https://doi.org/10.1124/dmd.121.000513
  • You have access
    The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide
    Claudia Garrido and Silke Leimkühler
    Drug Metabolism and Disposition September 2021, 49 (9) 729-735; DOI: https://doi.org/10.1124/dmd.121.000549
  • You have access
    Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs
    Andy Pike, Barry Jones, Roshini Markandu and Daniel O’Neill
    Drug Metabolism and Disposition September 2021, 49 (9) 736-742; DOI: https://doi.org/10.1124/dmd.121.000409
  • Open Access
    Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance
    Kirk D. Kozminski, Jangir Selimkhanov, Scott Heyward and Michael A. Zientek
    Drug Metabolism and Disposition September 2021, 49 (9) 743-749; DOI: https://doi.org/10.1124/dmd.120.000313
  • Comparative Hepatic and Intestinal Efflux Transport of Statins
    Open Access
    Comparative Hepatic and Intestinal Efflux Transport of Statins
    Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi
    Drug Metabolism and Disposition September 2021, 49 (9) 750-759; DOI: https://doi.org/10.1124/dmd.121.000430
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    Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
    Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badee, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott and Stephen Fowler
    Drug Metabolism and Disposition September 2021, 49 (9) 760-769; DOI: https://doi.org/10.1124/dmd.121.000474
  • Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
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    Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
    Ran Zhang, Dan Xu, Yirui Zhang, Rui Wang, Na Yang, Yunge Lou, Haokai Zhao, Jiye Aa, Guangji Wang and Yuan Xie
    Drug Metabolism and Disposition September 2021, 49 (9) 770-779; DOI: https://doi.org/10.1124/dmd.121.000438
  • Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins
    Open Access
    Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins
    L. J. Stevens, A. Z. X. Zhu, P. P. Chothe, S. K. Chowdhury, J. M. Donkers, W. H. J. Vaes, C. A. J. Knibbe, I. P. J. Alwayn and E. van de Steeg
    Drug Metabolism and Disposition September 2021, 49 (9) 780-789; DOI: https://doi.org/10.1124/dmd.121.000521
  • You have access
    Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing
    Qian Yang and Albert P. Li
    Drug Metabolism and Disposition September 2021, 49 (9) 790-802; DOI: https://doi.org/10.1124/dmd.121.000424
  • MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/<em>SLCO2B1</em> in Caco-2 Cells
    You have access
    MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells
    Hisakazu Komori, Daichi Fujita, Yuma Shirasaki, Qiunan Zhu, Yui Iwamoto, Takeo Nakanishi, Miki Nakajima and Ikumi Tamai
    Drug Metabolism and Disposition September 2021, 49 (9) 803-809; DOI: https://doi.org/10.1124/dmd.121.000380
  • Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome
    Open Access
    Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome
    Ying Fang, Henry Johnson, Janet L. Anderl, Tony Muchamuel, Dustin McMinn, Christophe Morisseau, Bruce D. Hammock, Christopher Kirk and Jinhai Wang
    Drug Metabolism and Disposition September 2021, 49 (9) 810-821; DOI: https://doi.org/10.1124/dmd.120.000307
  • Open Access
    Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition
    Eric Gonzalez, Sankalp Jain, Pranav Shah, Nao Torimoto-Katori, Alexey Zakharov, Ðắc-Trung Nguyễn, Srilatha Sakamuru, Ruili Huang, Menghang Xia, R. Scott Obach, Cornelis E. C. A. Hop, Anton Simeonov and Xin Xu
    Drug Metabolism and Disposition September 2021, 49 (9) 822-832; DOI: https://doi.org/10.1124/dmd.120.000320
  • Oleuropein-Induced Acceleration of Cytochrome P450–Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α
    You have access
    Oleuropein-Induced Acceleration of Cytochrome P450–Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α
    Foteini Malliou, Christina E. Andriopoulou, Frank J. Gonzalez, Aristeidis Kofinas, Alexios-Leandros Skaltsounis and Maria Konstandi
    Drug Metabolism and Disposition September 2021, 49 (9) 833-843; DOI: https://doi.org/10.1124/dmd.120.000302
  • You have access
    Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population
    Sara N. Salerno, Fernando O. Carreño, Andrea N. Edginton, Michael Cohen-Wolkowiez and Daniel Gonzalez
    Drug Metabolism and Disposition September 2021, 49 (9) 844-855; DOI: https://doi.org/10.1124/dmd.120.000318
  • You have access
    Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
    Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan
    Drug Metabolism and Disposition September 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508

Erratum

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    Correction to “In Vivo-to-in Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach”
    Drug Metabolism and Disposition September 2021, 49 (9) 869; DOI: https://doi.org/10.1124/dmd.121.000367err
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Drug Metabolism and Disposition: 49 (9)
Drug Metabolism and Disposition
Vol. 49, Issue 9
1 Sep 2021
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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