Drug Metabolism and Disposition: 49 (9)

September 01, 2021; Volume 49,Issue 9

Articles

You have access
Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans
Shiori Honda, Tatsuki Fukami, Keiya Hirosawa, Takuya Tsujiguchi, Yongjie Zhang, Masataka Nakano, Shotaro Uehara, Yasuhiro Uno, Hiroshi Yamazaki and Miki Nakajima

Drug Metabolism and Disposition September 2021, 49 (9) 718-728; DOI: https://doi.org/10.1124/dmd.121.000513
You have access
The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide
Claudia Garrido and Silke Leimkühler

Drug Metabolism and Disposition September 2021, 49 (9) 729-735; DOI: https://doi.org/10.1124/dmd.121.000549
You have access
Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs
Andy Pike, Barry Jones, Roshini Markandu and Daniel O’Neill

Drug Metabolism and Disposition September 2021, 49 (9) 736-742; DOI: https://doi.org/10.1124/dmd.121.000409
Open Access
Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance
Kirk D. Kozminski, Jangir Selimkhanov, Scott Heyward and Michael A. Zientek

Drug Metabolism and Disposition September 2021, 49 (9) 743-749; DOI: https://doi.org/10.1124/dmd.120.000313
Open Access
Comparative Hepatic and Intestinal Efflux Transport of Statins
Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi

Drug Metabolism and Disposition September 2021, 49 (9) 750-759; DOI: https://doi.org/10.1124/dmd.121.000430
You have access
Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badee, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott and Stephen Fowler

Drug Metabolism and Disposition September 2021, 49 (9) 760-769; DOI: https://doi.org/10.1124/dmd.121.000474
You have access
Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease
Ran Zhang, Dan Xu, Yirui Zhang, Rui Wang, Na Yang, Yunge Lou, Haokai Zhao, Jiye Aa, Guangji Wang and Yuan Xie

Drug Metabolism and Disposition September 2021, 49 (9) 770-779; DOI: https://doi.org/10.1124/dmd.121.000438
Open Access
Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins
L. J. Stevens, A. Z. X. Zhu, P. P. Chothe, S. K. Chowdhury, J. M. Donkers, W. H. J. Vaes, C. A. J. Knibbe, I. P. J. Alwayn and E. van de Steeg

Drug Metabolism and Disposition September 2021, 49 (9) 780-789; DOI: https://doi.org/10.1124/dmd.121.000521
You have access
Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing
Qian Yang and Albert P. Li

Drug Metabolism and Disposition September 2021, 49 (9) 790-802; DOI: https://doi.org/10.1124/dmd.121.000424
You have access
MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells
Hisakazu Komori, Daichi Fujita, Yuma Shirasaki, Qiunan Zhu, Yui Iwamoto, Takeo Nakanishi, Miki Nakajima and Ikumi Tamai

Drug Metabolism and Disposition September 2021, 49 (9) 803-809; DOI: https://doi.org/10.1124/dmd.121.000380
Open Access
Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome
Ying Fang, Henry Johnson, Janet L. Anderl, Tony Muchamuel, Dustin McMinn, Christophe Morisseau, Bruce D. Hammock, Christopher Kirk and Jinhai Wang

Drug Metabolism and Disposition September 2021, 49 (9) 810-821; DOI: https://doi.org/10.1124/dmd.120.000307
Open Access
Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition
Eric Gonzalez, Sankalp Jain, Pranav Shah, Nao Torimoto-Katori, Alexey Zakharov, Ðắc-Trung Nguyễn, Srilatha Sakamuru, Ruili Huang, Menghang Xia, R. Scott Obach, Cornelis E. C. A. Hop, Anton Simeonov and Xin Xu

Drug Metabolism and Disposition September 2021, 49 (9) 822-832; DOI: https://doi.org/10.1124/dmd.120.000320
You have access
Oleuropein-Induced Acceleration of Cytochrome P450–Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α
Foteini Malliou, Christina E. Andriopoulou, Frank J. Gonzalez, Aristeidis Kofinas, Alexios-Leandros Skaltsounis and Maria Konstandi

Drug Metabolism and Disposition September 2021, 49 (9) 833-843; DOI: https://doi.org/10.1124/dmd.120.000302
You have access
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population
Sara N. Salerno, Fernando O. Carreño, Andrea N. Edginton, Michael Cohen-Wolkowiez and Daniel Gonzalez

Drug Metabolism and Disposition September 2021, 49 (9) 844-855; DOI: https://doi.org/10.1124/dmd.120.000318
You have access
Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan

Drug Metabolism and Disposition September 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508