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Research ArticleArticle

Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4

Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan
Drug Metabolism and Disposition September 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508
Lloyd Wei Tat Tang
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Jian Wei Teng
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Ravi Kumar Verma
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Siew Kwan Koh
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Lei Zhou
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Mei Lin Go
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Hao Fan
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Eric Chun Yong Chan
Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
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Article Information

vol. 49 no. 9 856-868
DOI 
https://doi.org/10.1124/dmd.121.000508
PubMed 
34326139

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 19, 2021
  • Accepted July 8, 2021
  • Published online September 27, 2021.

Article Versions

  • Earlier version (July 29, 2021 - 11:10).
  • Earlier version (August 2, 2021 - 10:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lloyd Wei Tat Tang,
  2. Jian Wei Teng,
  3. Ravi Kumar Verma,
  4. Siew Kwan Koh,
  5. Lei Zhou,
  6. Mei Lin Go,
  7. Hao Fan, and
  8. Eric Chun Yong Chan
  1. Department of Pharmacy, Faculty of Science (L.W.T.T., J.W.T, M.L.G., E.C.Y.C.) and Department of Ophthalmology, Yong Loo Lin School of Medicine (L.Z.), National University of Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore (R.K.V., H.F.); Singapore Eye Research Institute, Singapore (S.K.K., L.Z.); and Ophthalmology and Visual Sciences Academia Clinical Program, Duke-National University of Singapore Medical School, Singapore (L.Z.)
  1. Address Correspondence to:
    Professor Eric Chun Yong Chan, Department of Pharmacy, National University of Singapore, 18 Science DR. 4, Singapore 117543. E-mail: phaccye{at}nus.edu.sg
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Drug Metabolism and Disposition: 49 (9)
Drug Metabolism and Disposition
Vol. 49, Issue 9
1 Sep 2021
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Research ArticleArticle

Inhibition and Inactivation of CYP3A4 by Infigratinib

Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan
Drug Metabolism and Disposition September 1, 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508

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Research ArticleArticle

Inhibition and Inactivation of CYP3A4 by Infigratinib

Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan
Drug Metabolism and Disposition September 1, 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508
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