Table of Contents

Articles

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  Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2–Positive Tumors

  Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber

  Drug Metabolism and Disposition January 2022, 50 (1) 8-16; DOI: https://doi.org/10.1124/dmd.121.000503
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  Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells

  Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga

  Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
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  Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver

  J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce

  Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
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  Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model

  Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey

  Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
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  Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms

  Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang

  Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649
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  Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

  Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

  Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
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  New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments

  Catherine M. Pastor and Kim L.R. Brouwer

  Drug Metabolism and Disposition January 2022, 50 (1) 58-64; DOI: https://doi.org/10.1124/dmd.121.000546