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Drug Metabolism & Disposition

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  • Articles
    • Current Issue
    • Fast Forward
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Index by author

January 01, 2022; Volume 50,Issue 1
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

B

  1. Barbier, Olivier

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
  2. Bart, Aaron G.

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  3. Brink, Andreas

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  4. Brouwer, Kim L.R.

    1. You have access
      New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments
      Catherine M. Pastor and Kim L.R. Brouwer
      Drug Metabolism and Disposition January 2022, 50 (1) 58-64; DOI: https://doi.org/10.1124/dmd.121.000546

C

  1. Chen, Shujuan

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
  2. Cleary, Yumi

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  3. Collins, Joseph M.

    1. You have access
      Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
      Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang
      Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649

D

  1. Dinh, Jean C.

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623

F

  1. Fowler, Stephen

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

G

  1. Gaedigk, Andrea

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
  2. Günther, Andreas

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

H

  1. Hanioka, Nobumitsu

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  2. Heinig, Katja

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  3. Husser, Christophe

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

I

  1. Ito, Mina

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  2. Iwao, Takahiro

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605

K

  1. Kitaguchi, Takashi

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  2. Kletzl, Heidemarie

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  3. Kobayashi, Kazuhiro

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  4. Kratochwil, Nicole

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

L

  1. Lai, Yuen Sze

    1. You have access
      Overview of Current Herb–Drug Interaction Databases
      Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo
      Drug Metabolism and Disposition January 2022, 50 (1) 86-94; DOI: https://doi.org/10.1124/dmd.121.000420
  2. Leeder, J. Steven

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
  3. Li, Fengcheng

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
  4. Li, Zhaorong

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
  5. Linderman, Jennifer J.

    1. You have access
      Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2–Positive Tumors
      Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber
      Drug Metabolism and Disposition January 2022, 50 (1) 8-16; DOI: https://doi.org/10.1124/dmd.121.000503
  6. Loadman, Paul M.

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  7. Lu, Rong

    1. You have access
      Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
      Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang
      Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649

M

  1. Man Ip, Chung

    1. You have access
      Overview of Current Herb–Drug Interaction Databases
      Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo
      Drug Metabolism and Disposition January 2022, 50 (1) 86-94; DOI: https://doi.org/10.1124/dmd.121.000420
  2. Maruo, Yoshihiro

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
  3. Matsunaga, Tamihide

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  4. Menezes, Bruna

    1. You have access
      Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2–Positive Tumors
      Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber
      Drug Metabolism and Disposition January 2022, 50 (1) 8-16; DOI: https://doi.org/10.1124/dmd.121.000503
  5. Mennillo, Elvira

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
  6. Mizota, Taisei

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  7. Morais, Goreti

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  8. Mueller, Lutz

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

O

  1. Ogawa, Isamu

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  2. Ohno, Katsutoshi

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605

P

  1. Pastor, Catherine M.

    1. You have access
      New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments
      Catherine M. Pastor and Kim L.R. Brouwer
      Drug Metabolism and Disposition January 2022, 50 (1) 58-64; DOI: https://doi.org/10.1124/dmd.121.000546
  2. Pearce, Robin E.

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
  3. Poirier, Agnès

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  4. Pors, Klaus

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  5. Prasad, Bhagwat

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623

Q

  1. Qiu, Shimeng

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605

R

  1. Ragueneau-Majlessi, Isabelle

    1. You have access
      Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the US Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
      Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2022, 50 (1) 1-7; DOI: https://doi.org/10.1124/dmd.121.000401

S

  1. Savage, Mark

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  2. Scott, Emily E.

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  3. Staggs, Vincent S.

    1. You have access
      Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
      J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
      Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
  4. Stillhart, Cordula

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

T

  1. Tanaka, Mitsuru

    1. Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      You have access
      Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
      Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
      Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
  2. Thurber, Greg M.

    1. You have access
      Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2–Positive Tumors
      Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber
      Drug Metabolism and Disposition January 2022, 50 (1) 8-16; DOI: https://doi.org/10.1124/dmd.121.000503
  3. Tuerck, Dietrich

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  4. Tukey, Robert H.

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644

U

  1. Ullah, Mohammed

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
  2. Umehara, Kenichi

    1. Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the <em>SMN2</em> mRNA Splicing Modifier Risdiplam
      Open Access
      Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
      Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier
      Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563

V

  1. Vangala, Venu R.

    1. You have access
      Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
      Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
      Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
  2. Verreault, Melanie

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644

W

  1. Wang, Danxin

    1. You have access
      Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
      Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang
      Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649
  2. Wang, Xinwen

    1. You have access
      Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
      Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang
      Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649
  3. Wang, Yan

    1. You have access
      Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the US Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
      Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2022, 50 (1) 1-7; DOI: https://doi.org/10.1124/dmd.121.000401
  4. Weber, Andre A.

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644

Y

  1. Yang, Xiaojing

    1. You have access
      Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
      Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
  2. Yin, Jiayi

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
  3. Yu, Jingjing

    1. You have access
      Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the US Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
      Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2022, 50 (1) 1-7; DOI: https://doi.org/10.1124/dmd.121.000401
  4. Yu, Lushan

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419

Z

  1. Zeng, Su

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
  2. Zhang, Yufeng

    1. You have access
      Overview of Current Herb–Drug Interaction Databases
      Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo
      Drug Metabolism and Disposition January 2022, 50 (1) 86-94; DOI: https://doi.org/10.1124/dmd.121.000420
  3. Zhu, Feng

    1. You have access
      Feature, Function, and Information of Drug Transporter–Related Databases
      Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng
      Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
  4. Zhu, Hao-Jie

    1. You have access
      Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms
      Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang
      Drug Metabolism and Disposition January 2022, 50 (1) 43-48; DOI: https://doi.org/10.1124/dmd.121.000649
  5. Zuo, Zhong

    1. You have access
      Overview of Current Herb–Drug Interaction Databases
      Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo
      Drug Metabolism and Disposition January 2022, 50 (1) 86-94; DOI: https://doi.org/10.1124/dmd.121.000420
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Drug Metabolism and Disposition: 50 (1)
Drug Metabolism and Disposition
Vol. 50, Issue 1
1 Jan 2022
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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