Research ArticleArticle
Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
Takashi Kitaguchi
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Taisei Mizota
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Mina Ito
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Katsutoshi Ohno
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Kazuhiro Kobayashi
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Isamu Ogawa
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Shimeng Qiu
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Takahiro Iwao
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Nobumitsu Hanioka
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Mitsuru Tanaka
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)
Tamihide Matsunaga
Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., Hachioji, Japan (T.K., T.M., M.I., K.O., K.K., M.T.); Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan (I.O., S.Q., T.I., T.M.); and Department of Health Pharmacy, Yokohama University of Pharmacy, Yokohama, Japan (N.H.)

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Membrane Permeability and UGT Metabolism in hiPSC-SIECs
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
Drug Metabolism and Disposition January 1, 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
Research ArticleArticle
Membrane Permeability and UGT Metabolism in hiPSC-SIECs
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga
Drug Metabolism and Disposition January 1, 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605
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