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Research ArticleArticle

Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver

J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
J. Steven Leeder
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Jean C. Dinh
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Andrea Gaedigk
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Vincent S. Staggs
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Bhagwat Prasad
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Robin E. Pearce
Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
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Article Information

vol. 50 no. 1 24-32
DOI 
https://doi.org/10.1124/dmd.121.000623
PubMed 
34686522

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 22, 2021
  • Accepted October 20, 2021
  • Published online December 15, 2021.

Article Versions

  • Earlier version (October 22, 2021 - 10:29).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. Steven Leeder,
  2. Jean C. Dinh1,
  3. Andrea Gaedigk,
  4. Vincent S. Staggs,
  5. Bhagwat Prasad, and
  6. Robin E. Pearce
  1. Certara, Princeton, NJ (J.C.D.); Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics and Children’s Mercy Research Institute, Children's Mercy Kansas City, Kansas City, Missouri (J.S.L., J.C.D., A.G., V.S.S., R.E.P.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.)
  1. Address correspondence to:
    Dr. J. Steven Leeder, Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, 2401 Gillham Rd, Kansas City, MO 64108. E-mail: sleeder{at}cmh.edu
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Oct 202123726161
Nov 202129010133
Dec 20213792136
Jan 20223574251
Feb 20222631215
Mar 20223172021
Apr 20223141022
May 202212675

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Drug Metabolism and Disposition: 50 (1)
Drug Metabolism and Disposition
Vol. 50, Issue 1
1 Jan 2022
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Research ArticleArticle

Ontogeny of MPPGL in Pediatric Liver

J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
Drug Metabolism and Disposition January 1, 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623

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Research ArticleArticle

Ontogeny of MPPGL in Pediatric Liver

J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce
Drug Metabolism and Disposition January 1, 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
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