Research ArticleArticle
Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model
Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
Drug Metabolism and Disposition January 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
Elvira Mennillo
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Xiaojing Yang
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Andre A. Weber
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Yoshihiro Maruo
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Melanie Verreault
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Olivier Barbier
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Shujuan Chen
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
Robert H. Tukey
Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (E.M., X.Y., A.A.W., S.C., R.H.T.); Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan (Y.M.); and Laboratory of Moléculaire Pharmacology, Centre de Recherche du CHU de Québec, Faculté of Pharmacie, Université Laval Québec, Québec, Canada (M.V., O.B.)
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Research ArticleArticle
Humanized UGT1A1 Mice and Irinotecan Toxicity
Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
Drug Metabolism and Disposition January 1, 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
Research ArticleArticle
Humanized UGT1A1 Mice and Irinotecan Toxicity
Elvira Mennillo, Xiaojing Yang, Andre A. Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey
Drug Metabolism and Disposition January 1, 2022, 50 (1) 33-42; DOI: https://doi.org/10.1124/dmd.121.000644
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