Research ArticleArticle
Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
Aaron G. Bart
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
Goreti Morais
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
Venu R. Vangala
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
Paul M. Loadman
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
Klaus Pors
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
Emily E. Scott
Program in Biophysics (A.G.B., E.E.S.) and Departments of Medicinal Chemistry and Pharmacology and Biological Chemistry (E.E.S.), University of Michigan, Ann Arbor, Michigan; Institute of Cancer Therapeutics (G.M., P.M.L., K.P.), Centre for Pharmaceutical Engineering Science (V.R.V.), Faculty of Life Sciences, University of Bradford, United Kingdom
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P450 Activation of Duocarmycin Prodrugs
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
Drug Metabolism and Disposition January 1, 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
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