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Drug Metabolism & Disposition

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Table of Contents

October 01, 2022; Volume 50,Issue 10

Special Section on Mechanistic and Translational Research on Transporters in Toxicology

  • You have access
    Special Section on Mechanistic and Translational Research on Transporters in Toxicology–Editorial
    Yurong Lai and Xiao-bo Zhong
    Drug Metabolism and Disposition October 2022, 50 (10) 1361-1363; DOI: https://doi.org/10.1124/dmd.122.001042
  • Regulation of Placental Efflux Transporters during Pregnancy Complications
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    Regulation of Placental Efflux Transporters during Pregnancy Complications
    Danielle Kozlosky, Emily Barrett and Lauren M. Aleksunes
    Drug Metabolism and Disposition October 2022, 50 (10) 1364-1375; DOI: https://doi.org/10.1124/dmd.121.000449
  • Role and Regulation of Hepatobiliary ATP-Binding Cassette Transporters during Chemical-Induced Liver Injury
    You have access
    Role and Regulation of Hepatobiliary ATP-Binding Cassette Transporters during Chemical-Induced Liver Injury
    Carolina I. Ghanem and Jose E. Manautou
    Drug Metabolism and Disposition October 2022, 50 (10) 1376-1388; DOI: https://doi.org/10.1124/dmd.121.000450
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    Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity
    Joseph L. Jilek, Kayla L. Frost, Solène Marie, Cassandra M. Myers, Michael Goedken, Stephen H. Wright and Nathan J. Cherrington
    Drug Metabolism and Disposition October 2022, 50 (10) 1389-1395; DOI: https://doi.org/10.1124/dmd.121.000451
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    Perfluorinated Carboxylic Acids with Increasing Carbon Chain Lengths Upregulate Amino Acid Transporters and Modulate Compensatory Response of Xenobiotic Transporters in HepaRG Cells
    Joe Jongpyo Lim, Youjun Suh, Elaine M. Faustman and Julia Yue Cui
    Drug Metabolism and Disposition October 2022, 50 (10) 1396-1413; DOI: https://doi.org/10.1124/dmd.121.000477
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    Effect of Chronic Cadmium Exposure on Brain and Liver Transporters and Drug-Metabolizing Enzymes in Male and Female Mice Genetically Predisposed to Alzheimer’s Disease
    Hao Wang, Liang Zhang, Zhengui Xia and Julia Yue Cui
    Drug Metabolism and Disposition October 2022, 50 (10) 1414-1428; DOI: https://doi.org/10.1124/dmd.121.000453

Articles

  • Open Access
    Physiologically Based Pharmacokinetic Modeling To Predict Drug-Biologic Interactions with Cytokine Modulators: Are These Relevant and Is Interleukin-6 Enough?
    Kuan-Fu Chen, Hannah M. Jones and Katherine L. Gill
    Drug Metabolism and Disposition October 2022, 50 (10) 1322-1331; DOI: https://doi.org/10.1124/dmd.122.000926
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    Inhibition of Cytochrome P450 2J2-Mediated Metabolism of Rivaroxaban and Arachidonic Acid by Ibrutinib and Osimertinib
    Ziteng Wang and Eric Chun Yong Chan
    Drug Metabolism and Disposition October 2022, 50 (10) 1332-1341; DOI: https://doi.org/10.1124/dmd.122.000928
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    Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic Acid as a Urinary Biomarker of CYP2D6 Activity
    Andrew C Behrle, Justin Douglas, J. Steven Leeder and Leon van Haandel
    Drug Metabolism and Disposition October 2022, 50 (10) 1342-1351; DOI: https://doi.org/10.1124/dmd.122.000957
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    Mesenchymal Stem Cell Fates in Murine Acute Liver Injury and Chronic Liver Fibrosis Induced by Carbon Tetrachloride
    Chenhui Ma, Li Han, Jiajun Wu, Feng Tang, Qiangqiang Deng, Ting He, Zhitao Wu, Chen Ma, Wei Huang, Ruimin Huang and Guoyu Pan
    Drug Metabolism and Disposition October 2022, 50 (10) 1352-1360; DOI: https://doi.org/10.1124/dmd.122.000958
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In this issue

Drug Metabolism and Disposition: 50 (10)
Drug Metabolism and Disposition
Vol. 50, Issue 10
1 Oct 2022
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Editorial Board (PDF)
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  • Special Section on Mechanistic and Translational Research on Transporters in Toxicology
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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