Research ArticleArticle
Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver
Sheena Sharma, Deepak Ahire, Abdul Basit, Maria Lajoie, Christina Wang, Min S. Lee, Diana L. Blithe, John K. Amory, Dilip K. Singh, Scott Heyward and Bhagwat Prasad
Drug Metabolism and Disposition December 2022, 50 (12) 1493-1500; DOI: https://doi.org/10.1124/dmd.122.001041
Sheena Sharma
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Deepak Ahire
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Abdul Basit
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Maria Lajoie
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Christina Wang
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Min S. Lee
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Diana L. Blithe
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
John K. Amory
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Dilip K. Singh
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Scott Heyward
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
Bhagwat Prasad
Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.S., D.A., A.B., D.K.S., B.P.); The Lundquist Institute at Harbor UCLA Medical Center, Torrance, California (M.L., C.W.); Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (M.S.L., D.L.B.); Department of Medicine, University of Washington School of Medicine, Seattle, Washington (J.K.A.); and BioIVT, Halethorpe, Maryland (S.H.)
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Role of UGT2B17 Enzyme in DMA Metabolism
Sheena Sharma, Deepak Ahire, Abdul Basit, Maria Lajoie, Christina Wang, Min S. Lee, Diana L. Blithe, John K. Amory, Dilip K. Singh, Scott Heyward and Bhagwat Prasad
Drug Metabolism and Disposition December 1, 2022, 50 (12) 1493-1500; DOI: https://doi.org/10.1124/dmd.122.001041
Research ArticleArticle
Role of UGT2B17 Enzyme in DMA Metabolism
Sheena Sharma, Deepak Ahire, Abdul Basit, Maria Lajoie, Christina Wang, Min S. Lee, Diana L. Blithe, John K. Amory, Dilip K. Singh, Scott Heyward and Bhagwat Prasad
Drug Metabolism and Disposition December 1, 2022, 50 (12) 1493-1500; DOI: https://doi.org/10.1124/dmd.122.001041
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