Table of Contents

Articles

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  Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work

  Anna-Karin Sohlenius-Sternbeck and Ylva Terelius

  Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552
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  Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses

  John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser

  Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638
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  Open Access

  Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model

  Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang

  Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718
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  Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice

  Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li

  Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633
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  Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone

  Hong Wei and Albert P. Li

  Drug Metabolism and Disposition February 2022, 50 (2) 140-149; DOI: https://doi.org/10.1124/dmd.121.000645
• Open Access

  Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects

  Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon

  Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632
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  The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

  Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

  Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640
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  The Impact of Age and Genetics on Naltrexone Biotransformation

  Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

  Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646
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  Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia

  Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li

  Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681