Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

February 01, 2022; Volume 50,Issue 2

Commentary

  • You have access
    In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
    Malcolm Rowland, Michael S. Roberts and K. Sandy Pang
    Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637

Articles

  • Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
    You have access
    Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
    Anna-Karin Sohlenius-Sternbeck and Ylva Terelius
    Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552
  • Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
    You have access
    Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
    John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
    Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638
  • Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
    Open Access
    Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
    Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
    Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718
  • Open Access
    Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
    Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
    Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633
  • Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
    You have access
    Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
    Hong Wei and Albert P. Li
    Drug Metabolism and Disposition February 2022, 50 (2) 140-149; DOI: https://doi.org/10.1124/dmd.121.000645
  • Open Access
    Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
    Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
    Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632
  • The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
    You have access
    The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
    Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
    Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640
  • You have access
    The Impact of Age and Genetics on Naltrexone Biotransformation
    Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
    Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646
  • Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
    You have access
    Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
    Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
    Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 50 (2)
Drug Metabolism and Disposition
Vol. 50, Issue 2
1 Feb 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Commentary
  • Articles
  • Most Cited
  • Most Read
Loading
  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics