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Index by author

February 01, 2022; Volume 50,Issue 2

B

  1. Bai, Xue

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  2. Barzi, Mercedes

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  3. Berthold, Erin C.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Bissig, Karl-Dimiter

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  5. Bold, Peter

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

C

  1. Chavan, Hemantkumar

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  2. Chen, Si

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

D

  1. de Ligt, Rianne A. F.

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  2. Duan, Yabin

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

F

  1. Fullenwider, Cody L.

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

G

  1. Gu, Wenqi

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  2. Guner, Joie Z.

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  3. Guo, Lei

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

H

  1. Hakenjos, John M.

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  2. Hiranita, Takato

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  3. Ho, Nicholas P.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Ho, Thuy

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  5. Holmberg, Ann Aurell

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

J

  1. Jauhiainen, Alexandra

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  2. Jenkins, Gary J.

    1. Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
      Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638

  3. Jung, Sung Yun

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

K

  1. Kamble, Shyam H.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  2. Kozminski, Kirk D.

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  3. Krishnamurthy, Partha

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  4. Kuntz, Michelle A.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

L

  1. La, Linli

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  2. Leeder, J. Steven

    1. The Impact of Age and Genetics on Naltrexone Biotransformation
      Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
      Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646

  3. León, Francisco

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Li, Albert P.

    1. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
      Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
      Hong Wei and Albert P. Li
      Drug Metabolism and Disposition February 2022, 50 (2) 140-149; DOI: https://doi.org/10.1124/dmd.121.000645

  5. Li, Feng

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  6. Li, Xiangyang

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  7. Liu, Guiqin

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

M

  1. Ma, Junli

    1. Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
      Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638

  2. MacKenzie, Kevin R.

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  3. Matzuk, Martin M.

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  4. McCurdy, Christopher R.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  5. McMahon, Lance R.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  6. Mottinelli, Marco

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

N

  1. Necander, Sofia

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  2. Nolte, Whitney

    1. The Impact of Age and Genetics on Naltrexone Biotransformation
      Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
      Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646

  3. Nyshadham, Pranavanand

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

P

  1. Palmer, Stephen

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  2. Pang, K. Sandy

    1. In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
      Malcolm Rowland, Michael S. Roberts and K. Sandy Pang
      Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637

  3. Patel, Avi

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Patel, Reena

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  5. Pearce, Robin E.

    1. The Impact of Age and Genetics on Naltrexone Biotransformation
      Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
      Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646

  6. Pelay-Gimeno, Marta

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  7. Perloff, Elke S.

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  8. Prothon, Susanne

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  9. Psallidas, Ioannis

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

Q

  1. Qin, Xuan

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

R

  1. Raju, Kanumuri S.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  2. Ramsden, Diane

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  3. Restrepo, Luis F.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Roberts, Michael S.

    1. In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
      Malcolm Rowland, Michael S. Roberts and K. Sandy Pang
      Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637

  5. Rowland, Malcolm

    1. In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics
      Malcolm Rowland, Michael S. Roberts and K. Sandy Pang
      Drug Metabolism and Disposition February 2022, 50 (2) 187-190; DOI: https://doi.org/10.1124/dmd.121.000637

S

  1. Savaryn, John Paul

    1. Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
      Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638

  2. Senetra, Alexandria S.

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  3. Sharma, Abhisheak

    1. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
      Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Michelle A. Kuntz, Alexandria S. Senetra, Marco Mottinelli, Francisco León, Luis F. Restrepo, Avi Patel, Nicholas P. Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
      Drug Metabolism and Disposition February 2022, 50 (2) 158-167; DOI: https://doi.org/10.1124/dmd.121.000640

  4. Sidhu, Sharan

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  5. Sohlenius-Sternbeck, Anna-Karin

    1. Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
      Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
      Anna-Karin Sohlenius-Sternbeck and Ylva Terelius
      Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552

  6. Staggs, Vincent S.

    1. The Impact of Age and Genetics on Naltrexone Biotransformation
      Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
      Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646

  7. Stancil, Stephani L.

    1. The Impact of Age and Genetics on Naltrexone Biotransformation
      Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
      Drug Metabolism and Disposition February 2022, 50 (2) 168-173; DOI: https://doi.org/10.1124/dmd.121.000646

  8. Stresser, David M.

    1. Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
      Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638

  9. Sun, Jun

    1. Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses
      John Paul Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser
      Drug Metabolism and Disposition February 2022, 50 (2) 105-113; DOI: https://doi.org/10.1124/dmd.121.000638

T

  1. Terelius, Ylva

    1. Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
      Evaluation of ADMET Predictor in Early Discovery Drug Metabolism and Pharmacokinetics Project Work
      Anna-Karin Sohlenius-Sternbeck and Ylva Terelius
      Drug Metabolism and Disposition February 2022, 50 (2) 95-104; DOI: https://doi.org/10.1124/dmd.121.000552

V

  1. Verheij, Elwin R.

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

W

  1. Wählby Hamrén, Ulrika

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  2. Wang, Jin

    1. Open Access
      Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
      Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li
      Drug Metabolism and Disposition February 2022, 50 (2) 128-139; DOI: https://doi.org/10.1124/dmd.121.000633

  3. Wang, Qian

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  4. Wei, Hong

    1. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
      Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone
      Hong Wei and Albert P. Li
      Drug Metabolism and Disposition February 2022, 50 (2) 140-149; DOI: https://doi.org/10.1124/dmd.121.000645

  5. Weidolf, Lars

    1. Open Access
      Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
      Ann Aurell Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A. F. de Ligt, Elwin R. Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon
      Drug Metabolism and Disposition February 2022, 50 (2) 150-157; DOI: https://doi.org/10.1124/dmd.121.000632

  6. Whitcher-Johnstone, Andrea

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

Y

  1. Yang, Jianxin

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

Z

  1. Zhang, J. George

    1. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Open Access
      Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
      Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J. George Zhang
      Drug Metabolism and Disposition February 2022, 50 (2) 114-127; DOI: https://doi.org/10.1124/dmd.121.000718

  2. Zhou, Yang

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681

  3. Zhu, Junbo

    1. Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
      Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li
      Drug Metabolism and Disposition February 2022, 50 (2) 174-186; DOI: https://doi.org/10.1124/dmd.121.000681
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