Table of Contents

Articles

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  Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans

  Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J. Steven Leeder and Bhagwat Prasad

  Drug Metabolism and Disposition March 2022, 50 (3) 191-196; DOI: https://doi.org/10.1124/dmd.121.000805
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  Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species

  Abdul Basit, Peter W. Fan, S. Cyrus Khojasteh, Bernard P. Murray, Bill J. Smith, Scott Heyward and Bhagwat Prasad

  Drug Metabolism and Disposition March 2022, 50 (3) 197-203; DOI: https://doi.org/10.1124/dmd.121.000774
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  Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans

  Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda and Hiroyuki Kusuhara

  Drug Metabolism and Disposition March 2022, 50 (3) 204-213; DOI: https://doi.org/10.1124/dmd.121.000796
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  Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug–Drug Interactions

  Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott and Dietrich Tuerck

  Drug Metabolism and Disposition March 2022, 50 (3) 214-223; DOI: https://doi.org/10.1124/dmd.121.000720
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  CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na_V1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate

  Daigo Asano, Syoya Hamaue, Hamim Zahir, Hideyuki Shiozawa, Yumi Nishiya, Takako Kimura, Miho Kazui, Naotoshi Yamamura, Marie Ikeguchi, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Toshiyuki Watanabe, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari

  Drug Metabolism and Disposition March 2022, 50 (3) 235-242; DOI: https://doi.org/10.1124/dmd.121.000665
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  Contributions of Cathepsin A and Carboxylesterase 1 to the Hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis

  Jiapeng Li, Jian Shi, Jingcheng Xiao, Lana Tran, Xinwen Wang and Hao-Jie Zhu

  Drug Metabolism and Disposition March 2022, 50 (3) 243-248; DOI: https://doi.org/10.1124/dmd.120.000323
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  Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping

  Alyssa L. Dantonio, Angela C. Doran and R. Scott Obach

  Drug Metabolism and Disposition March 2022, 50 (3) 249-257; DOI: https://doi.org/10.1124/dmd.121.000758
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  Antisense Oligonucleotide In Vitro Protein Binding Determination in Plasma, Brain, and Cerebral Spinal Fluid Using Hybridization LC-MS/MS

  Guilherme Guimaraes, Long Yuan and Pei Li

  Drug Metabolism and Disposition March 2022, 50 (3) 268-276; DOI: https://doi.org/10.1124/dmd.121.000751
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  Factors Influencing Luciferase-Based Bioluminescent Imaging in Preclinical Models of Brain Tumor

  Minjee Kim, Shiv K. Gupta, Wenjuan Zhang, Surabhi Talele, Afroz S. Mohammad, Janice Laramy, Ann C. Mladek, Shuangling Zhang, Jann N. Sarkaria and William F. Elmquist

  Drug Metabolism and Disposition March 2022, 50 (3) 277-286; DOI: https://doi.org/10.1124/dmd.121.000597
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  Transplacental Pharmacokinetic Model of Digoxin Based on Ex Vivo Human Placental Perfusion Study

  Ken Kurosawa, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi and Koji Chiba

  Drug Metabolism and Disposition March 2022, 50 (3) 287-298; DOI: https://doi.org/10.1124/dmd.121.000648