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Drug Metabolism & Disposition

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Table of Contents

March 01, 2022; Volume 50,Issue 3

Minireview

  • Exploring Drug Metabolism by the Gut Microbiota: Modes of Metabolism and Experimental Approaches
    You have access
    Exploring Drug Metabolism by the Gut Microbiota: Modes of Metabolism and Experimental Approaches
    Pooja Dhurjad, Chinmayi Dhavaliker, Kajal Gupta and Rajesh Sonti
    Drug Metabolism and Disposition March 2022, 50 (3) 224-234; DOI: https://doi.org/10.1124/dmd.121.000669
  • You have access
    Future of Biotransformation Science in the Pharmaceutical Industry
    Valerie M. Kramlinger, Deepak Dalvie, Carley J.S. Heck, Amit S. Kalgutkar, James O’Neill, Dian Su, Aaron M. Teitelbaum and Rheem A. Totah
    Drug Metabolism and Disposition March 2022, 50 (3) 258-267; DOI: https://doi.org/10.1124/dmd.121.000658
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    Cynomolgus Monkey as an Emerging Animal Model to Study Drug Transporters: In Vitro, In Vivo, In Vitro-to-In Vivo Translation
    Hong Shen, Zheng Yang and A. David Rodrigues
    Drug Metabolism and Disposition March 2022, 50 (3) 299-319; DOI: https://doi.org/10.1124/dmd.121.000695

Articles

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    Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans
    Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J. Steven Leeder and Bhagwat Prasad
    Drug Metabolism and Disposition March 2022, 50 (3) 191-196; DOI: https://doi.org/10.1124/dmd.121.000805
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    Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species
    Abdul Basit, Peter W. Fan, S. Cyrus Khojasteh, Bernard P. Murray, Bill J. Smith, Scott Heyward and Bhagwat Prasad
    Drug Metabolism and Disposition March 2022, 50 (3) 197-203; DOI: https://doi.org/10.1124/dmd.121.000774
  • Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans
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    Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans
    Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda and Hiroyuki Kusuhara
    Drug Metabolism and Disposition March 2022, 50 (3) 204-213; DOI: https://doi.org/10.1124/dmd.121.000796
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    Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug–Drug Interactions
    Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott and Dietrich Tuerck
    Drug Metabolism and Disposition March 2022, 50 (3) 214-223; DOI: https://doi.org/10.1124/dmd.121.000720
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    CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
    Daigo Asano, Syoya Hamaue, Hamim Zahir, Hideyuki Shiozawa, Yumi Nishiya, Takako Kimura, Miho Kazui, Naotoshi Yamamura, Marie Ikeguchi, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Toshiyuki Watanabe, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari
    Drug Metabolism and Disposition March 2022, 50 (3) 235-242; DOI: https://doi.org/10.1124/dmd.121.000665
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    Contributions of Cathepsin A and Carboxylesterase 1 to the Hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis
    Jiapeng Li, Jian Shi, Jingcheng Xiao, Lana Tran, Xinwen Wang and Hao-Jie Zhu
    Drug Metabolism and Disposition March 2022, 50 (3) 243-248; DOI: https://doi.org/10.1124/dmd.120.000323
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    Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping
    Alyssa L. Dantonio, Angela C. Doran and R. Scott Obach
    Drug Metabolism and Disposition March 2022, 50 (3) 249-257; DOI: https://doi.org/10.1124/dmd.121.000758
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    Antisense Oligonucleotide In Vitro Protein Binding Determination in Plasma, Brain, and Cerebral Spinal Fluid Using Hybridization LC-MS/MS
    Guilherme Guimaraes, Long Yuan and Pei Li
    Drug Metabolism and Disposition March 2022, 50 (3) 268-276; DOI: https://doi.org/10.1124/dmd.121.000751
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    Factors Influencing Luciferase-Based Bioluminescent Imaging in Preclinical Models of Brain Tumor
    Minjee Kim, Shiv K. Gupta, Wenjuan Zhang, Surabhi Talele, Afroz S. Mohammad, Janice Laramy, Ann C. Mladek, Shuangling Zhang, Jann N. Sarkaria and William F. Elmquist
    Drug Metabolism and Disposition March 2022, 50 (3) 277-286; DOI: https://doi.org/10.1124/dmd.121.000597
  • Open Access
    Transplacental Pharmacokinetic Model of Digoxin Based on Ex Vivo Human Placental Perfusion Study
    Ken Kurosawa, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi and Koji Chiba
    Drug Metabolism and Disposition March 2022, 50 (3) 287-298; DOI: https://doi.org/10.1124/dmd.121.000648
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Drug Metabolism and Disposition: 50 (3)
Drug Metabolism and Disposition
Vol. 50, Issue 3
1 Mar 2022
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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