Article Figures & Data
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- Supplemental Data -
Supplemental Methods
Supplementary Figure 1. The relative mRNA expression levels of intestinal drug transporters and drug-metabolizing enzymes in human jejunal spheroid-derived cells and human jejunal tissue sections originating from 3 different subject (#1–#3).
Supplementary Figure 2. Simple mathematical modeling of intestinal absorption of drugs.
Supplementary Figure 3. Theoretical consideration of the relationship between CLA to B and FaFg.
Supplementary Figure 4. Correlation between in vitro estimated Fg values and in vivo human Fg values of CYP3A substrate drugs based on the two different estimation methods.
Supplementary Figure 5. Comparison of the metabolic activity mediated by CYP3A4/5 in the four independent experiments.
Supplementary Table 1. Source of chemicals used in this study.
Supplementary Table 2. Sequences of primers for mRNA quantification.
Supplementary Table 3. Analytical conditions for quantification of test compounds with LC–MS/MS.
Supplementary Table 4. MRM conditions for quantification of test compounds with LC–MS/MS.
Supplementary Table 5. Summary of the estimated intestinal availability (Fg) for CYP3A substrates based on Eq. (7).
- Supplemental Data -