Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)

Drug Metabolism and Pharmacokinetics Research Laboratories (D.A., H.S., Y.N., M.K., N.Y., Ta.S., S.I., C.Y., N.W.), Translational Science Department (M.I.), R&D Planning and Management Department (Ts.S.), and Medicinal Safety Research Laboratories (T.W.), Daiichi Sankyo Co., Ltd., Tokyo, Japan; Organic and Biomolecular Chemistry Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan (S.H., T.K.); Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, New Jersey (H.Z.); and Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (K.Y.)