Table of Contents

Articles

• Open Access

  Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance

  Lara Rosenberger, Judith Jenniches, Carolina von Essen, Anupam Khutia, Clemens Kühn, Andreas Marx, Katrin Georgi, Anna K. H. Hirsch, Rolf W. Hartmann and Lassina Badolo

  Drug Metabolism and Disposition April 2022, 50 (4) 320-326; DOI: https://doi.org/10.1124/dmd.121.000663
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  Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients

  P. Aviles, R. Altares, L. van Andel, R. Lubomirov, S. Fudio, H. Rosing, F. M. Márquez del Pino, M.M. Tibben, G. Benedit, L. Nan-Offeringa, X.E. Luepke Estefan, A. Francesch, A. Zeaiter, C. Cuevas, J.H.M. Schellens and J.H. Beijnen

  Drug Metabolism and Disposition April 2022, 50 (4) 327-340; DOI: https://doi.org/10.1124/dmd.121.000668
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  Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4

  Yingqiong Zhang, Yujia Chen, Binxin Dai, Mengru Bai, Shuanghui Lu, Nengming Lin, Hui Zhou and Huidi Jiang

  Drug Metabolism and Disposition April 2022, 50 (4) 341-350; DOI: https://doi.org/10.1124/dmd.121.000685
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  Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes

  Sumit Bansal, Mary F. Paine and Jashvant D. Unadkat

  Drug Metabolism and Disposition April 2022, 50 (4) 351-360; DOI: https://doi.org/10.1124/dmd.121.000734
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  In Vitro and In Vivo Metabolism of a Novel Antimitochondrial Cancer Metabolism Agent, CPI-613, in Rat and Human

  Vijay Bhasker Reddy, Lakmal Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther and Ke Hu

  Drug Metabolism and Disposition April 2022, 50 (4) 361-373; DOI: https://doi.org/10.1124/dmd.121.000726
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  Proteomic and Bioinformatics Analysis of Membrane Lipid Domains after Brij 98 Solubilization of Uninduced and Phenobarbital-Induced Rat Liver Microsomes: Defining the Membrane Localization of the P450 Enzyme System

  James R. Reed, Jessie J. Guidry and Wayne L. Backes

  Drug Metabolism and Disposition April 2022, 50 (4) 374-385; DOI: https://doi.org/10.1124/dmd.121.000752
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  Prediction of Maternal and Fetoplacental Concentrations of Cefazolin, Cefuroxime, and Amoxicillin during Pregnancy Using Bottom-Up Physiologically Based Pharmacokinetic Models

  Khaled Abduljalil, Jia Ning, Amita Pansari, Xian Pan and Masoud Jamei

  Drug Metabolism and Disposition April 2022, 50 (4) 386-400; DOI: https://doi.org/10.1124/dmd.121.000711
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  Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?

  Tsubasa Kameyama, Jasleen K. Sodhi and Leslie Z. Benet

  Drug Metabolism and Disposition April 2022, 50 (4) 401-412; DOI: https://doi.org/10.1124/dmd.121.000677
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  Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1

  R. Scott Obach

  Drug Metabolism and Disposition April 2022, 50 (4) 413-421; DOI: https://doi.org/10.1124/dmd.121.000776