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Drug Metabolism & Disposition

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Table of Contents

April 01, 2022; Volume 50,Issue 4

Special Section on Bile Acids, Drug Metabolism, and Toxicity

  • You have access
    Special Section on Bile Acids, Drug Metabolism, and Toxicity—Editorial
    Drug Metabolism and Disposition April 2022, 50 (4) 422-424; DOI: https://doi.org/10.1124/dmd.122.000835
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    Molecular Regulation of Bile Acid Homeostasis
    Supratim Choudhuri and Curtis D. Klaassen
    Drug Metabolism and Disposition April 2022, 50 (4) 425-455; DOI: https://doi.org/10.1124/dmd.121.000643
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    Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
    Rulaiha E. Taylor, Anisha Bhattacharya and Grace L. Guo
    Drug Metabolism and Disposition April 2022, 50 (4) 456-467; DOI: https://doi.org/10.1124/dmd.121.000388
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    Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes
    Daniel Rizzolo, Bo Kong, Stephanie Piekos, Liming Chen, Xiaobo Zhong, Jie Lu, Jian Shi, Hao-jie Zhu, Qian Yang, Albert Li, Linhao Li, Hongbing Wang, Anna Siemiątkowska, Celine Park, Leonid Kagan and Grace L. Guo
    Drug Metabolism and Disposition April 2022, 50 (4) 468-477; DOI: https://doi.org/10.1124/dmd.121.000416
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    Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
    Moumita Dutta, Joe Jongpyo Lim and Julia Yue Cui
    Drug Metabolism and Disposition April 2022, 50 (4) 478-491; DOI: https://doi.org/10.1124/dmd.121.000415
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    Strategies to Diagnose Nonalcoholic Steatohepatitis: A Novel Approach to Take Advantage of Pharmacokinetic Alterations
    Solène Marie, David K.K. Tripp and Nathan J. Cherrington
    Drug Metabolism and Disposition April 2022, 50 (4) 492-499; DOI: https://doi.org/10.1124/dmd.121.000413
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    The Complicated Role of Nuclear Factor Erythroid-Derived 2-Like 2 in Allergy and Asthma
    Cheryl E. Rockwell, Yining Jin, Allison P. Boss, Luca M. Kaiser and Saamera Awali
    Drug Metabolism and Disposition April 2022, 50 (4) 500-507; DOI: https://doi.org/10.1124/dmd.121.000414
  • Open Access
    Mechanisms by Which Inducers of Drug Metabolizing Enzymes Alter Thyroid Hormones in Rats
    Nichole R. Vansell
    Drug Metabolism and Disposition April 2022, 50 (4) 508-517; DOI: https://doi.org/10.1124/dmd.121.000498

Articles

  • Open Access
    Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance
    Lara Rosenberger, Judith Jenniches, Carolina von Essen, Anupam Khutia, Clemens Kühn, Andreas Marx, Katrin Georgi, Anna K. H. Hirsch, Rolf W. Hartmann and Lassina Badolo
    Drug Metabolism and Disposition April 2022, 50 (4) 320-326; DOI: https://doi.org/10.1124/dmd.121.000663
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    Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients
    P. Aviles, R. Altares, L. van Andel, R. Lubomirov, S. Fudio, H. Rosing, F. M. Márquez del Pino, M.M. Tibben, G. Benedit, L. Nan-Offeringa, X.E. Luepke Estefan, A. Francesch, A. Zeaiter, C. Cuevas, J.H.M. Schellens and J.H. Beijnen
    Drug Metabolism and Disposition April 2022, 50 (4) 327-340; DOI: https://doi.org/10.1124/dmd.121.000668
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    Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4
    Yingqiong Zhang, Yujia Chen, Binxin Dai, Mengru Bai, Shuanghui Lu, Nengming Lin, Hui Zhou and Huidi Jiang
    Drug Metabolism and Disposition April 2022, 50 (4) 341-350; DOI: https://doi.org/10.1124/dmd.121.000685
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    Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes
    Sumit Bansal, Mary F. Paine and Jashvant D. Unadkat
    Drug Metabolism and Disposition April 2022, 50 (4) 351-360; DOI: https://doi.org/10.1124/dmd.121.000734
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    In Vitro and In Vivo Metabolism of a Novel Antimitochondrial Cancer Metabolism Agent, CPI-613, in Rat and Human
    Vijay Bhasker Reddy, Lakmal Boteju, Asela Boteju, Li Shen, Kelem Kassahun, Nageshwar Reddy, Adrian Sheldon, Sanjeev Luther and Ke Hu
    Drug Metabolism and Disposition April 2022, 50 (4) 361-373; DOI: https://doi.org/10.1124/dmd.121.000726
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    Proteomic and Bioinformatics Analysis of Membrane Lipid Domains after Brij 98 Solubilization of Uninduced and Phenobarbital-Induced Rat Liver Microsomes: Defining the Membrane Localization of the P450 Enzyme System
    James R. Reed, Jessie J. Guidry and Wayne L. Backes
    Drug Metabolism and Disposition April 2022, 50 (4) 374-385; DOI: https://doi.org/10.1124/dmd.121.000752
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    Prediction of Maternal and Fetoplacental Concentrations of Cefazolin, Cefuroxime, and Amoxicillin during Pregnancy Using Bottom-Up Physiologically Based Pharmacokinetic Models
    Khaled Abduljalil, Jia Ning, Amita Pansari, Xian Pan and Masoud Jamei
    Drug Metabolism and Disposition April 2022, 50 (4) 386-400; DOI: https://doi.org/10.1124/dmd.121.000711
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    Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?
    Tsubasa Kameyama, Jasleen K. Sodhi and Leslie Z. Benet
    Drug Metabolism and Disposition April 2022, 50 (4) 401-412; DOI: https://doi.org/10.1124/dmd.121.000677
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    Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1
    R. Scott Obach
    Drug Metabolism and Disposition April 2022, 50 (4) 413-421; DOI: https://doi.org/10.1124/dmd.121.000776

Erratum

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    Correction to “Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?”
    Drug Metabolism and Disposition April 2022, 50 (4) 518; DOI: https://doi.org/10.1124/dmd.121.000677err
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Drug Metabolism and Disposition: 50 (4)
Drug Metabolism and Disposition
Vol. 50, Issue 4
1 Apr 2022
  • Table of Contents
  • Table of Contents (PDF)
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  • Special Section on Bile Acids, Drug Metabolism, and Toxicity
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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