Table of Contents

Articles

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  Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model

  Mayur K. Ladumor and Jashvant D. Unadkat

  Drug Metabolism and Disposition May 2022, 50 (5) 519-528; DOI: https://doi.org/10.1124/dmd.121.000789
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  Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A

  Lloyd Wei Tat Tang, Wan Wei, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan and Eric Chun Yong Chan

  Drug Metabolism and Disposition May 2022, 50 (5) 529-540; DOI: https://doi.org/10.1124/dmd.121.000804
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  Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

  Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

  Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
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  Inhibition of Human UDP-Glucuronosyltransferases1A1–Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin, and Hyperoside Is Responsible for Herb (Shuang-Huang-Lian)-Induced Jaundice

  Xiaolei Yang, Guanghao Zhu, Ying Zhang, Xubo Wu, Bei Liu, Ye Liu, Qing Yang, Wandi Du, Jingru Liang, Jiarong Hu, Ping Yang, Guangbo Ge, Weimin Cai and Guo Ma

  Drug Metabolism and Disposition May 2022, 50 (5) 552-565; DOI: https://doi.org/10.1124/dmd.121.000714
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  Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes

  Florian Klammers, Andreas Goetschi, Aynur Ekiciler, Isabelle Walter, Neil Parrott, Stephen Fowler and Kenichi Umehara

  Drug Metabolism and Disposition May 2022, 50 (5) 566-575; DOI: https://doi.org/10.1124/dmd.121.000765
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  Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans

  Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh and Amit S. Kalgutkar

  Drug Metabolism and Disposition May 2022, 50 (5) 576-590; DOI: https://doi.org/10.1124/dmd.121.000801
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  E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice

  Zhigang Wang, Lu Gao, Shujing Ren, Guanghui Sun, Yanke Lin, Shuai Wang and Baojian Wu

  Drug Metabolism and Disposition May 2022, 50 (5) 591-599; DOI: https://doi.org/10.1124/dmd.121.000790
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  Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism

  Upendra P. Dahal, Brooke M. Rock, John Rodgers, Xiaomeng Shen, Zhe Wang and Jan L. Wahlstrom

  Drug Metabolism and Disposition May 2022, 50 (5) 600-612; DOI: https://doi.org/10.1124/dmd.121.000798
• Open Access

  Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model

  Jinfu Peng, Mayur K. Ladumor and Jashvant D. Unadkat

  Drug Metabolism and Disposition May 2022, 50 (5) 613-623; DOI: https://doi.org/10.1124/dmd.121.000733
• Open Access

  Determination of Acyl-, O-, and N-Glucuronide Using Chemical Derivatization Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry

  Yukuang Guo, Abhi Shah, Eugene Oh, Swapan K. Chowdhury and Xiaochun Zhu

  Drug Metabolism and Disposition May 2022, 50 (5) 716-724; DOI: https://doi.org/10.1124/dmd.122.000832