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Drug Metabolism & Disposition

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Table of Contents

May 01, 2022; Volume 50,Issue 5

Special Section on Drug Metabolism in Liver Injury and Repair

  • You have access
    Special Section On Drug Metabolism in Liver Injury and Repair—Editorial
    Xiao-bo Zhong and Yurong Lai
    Drug Metabolism and Disposition May 2022, 50 (5) 634-635; DOI: https://doi.org/10.1124/dmd.122.000869
  • You have access
    Nuclear Receptor-Mediated Hepatomegaly and Liver Regeneration: An Update
    Pengfei Zhao, Shicheng Fan, Yue Gao, Min Huang and Huichang Bi
    Drug Metabolism and Disposition May 2022, 50 (5) 636-645; DOI: https://doi.org/10.1124/dmd.121.000454
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    Roles of Cofactors in Drug-Induced Liver Injury: Drug Metabolism and Beyond
    Ruizhi Gu, Alina Liang, Grace Liao, Isabelle To, Amina Shehu and Xiaochao Ma
    Drug Metabolism and Disposition May 2022, 50 (5) 646-654; DOI: https://doi.org/10.1124/dmd.121.000457
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    Metabolic Activation and Hepatotoxicity of Furan-Containing Compounds
    Min Tian, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition May 2022, 50 (5) 655-670; DOI: https://doi.org/10.1124/dmd.121.000458
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    Novel Clinical Biomarkers for Drug-Induced Liver Injury
    Youhao Chen, Shaoxing Guan, Yanping Guan, Siyuan Tang, Yanying Zhou, Xueding Wang, Huichang Bi and Min Huang
    Drug Metabolism and Disposition May 2022, 50 (5) 671-684; DOI: https://doi.org/10.1124/dmd.121.000732
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    Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights
    Yangliu Xia, Mingrui Yan, Ping Wang, Keisuke Hamada, Nana Yan, Haiping Hao, Frank J. Gonzalez and Tingting Yan
    Drug Metabolism and Disposition May 2022, 50 (5) 685-693; DOI: https://doi.org/10.1124/dmd.121.000455
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    Alterations of Cytochrome P450–Mediated Drug Metabolism during Liver Repair and Regeneration after Acetaminophen-Induced Liver Injury in Mice
    Yifan Bao, Mi Phan, Junjie Zhu, Xiaochao Ma, José E. Manautou and Xiao-bo Zhong
    Drug Metabolism and Disposition May 2022, 50 (5) 694-703; DOI: https://doi.org/10.1124/dmd.121.000459
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    Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells
    Xiaofei Wang, Yihang Yu, Pei Wang, Kun Yang, Yiting Wang, Liang Yan, Xiao-bo Zhong and Lirong Zhang
    Drug Metabolism and Disposition May 2022, 50 (5) 704-715; DOI: https://doi.org/10.1124/dmd.121.000693

Minireview

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    Adenosine-to-Inosine RNA Editing and N6-Methyladenosine Modification Modulating Expression of Drug Metabolizing Enzymes
    Masataka Nakano and Miki Nakajima
    Drug Metabolism and Disposition May 2022, 50 (5) 624-633; DOI: https://doi.org/10.1124/dmd.121.000390

Articles

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    Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model
    Mayur K. Ladumor and Jashvant D. Unadkat
    Drug Metabolism and Disposition May 2022, 50 (5) 519-528; DOI: https://doi.org/10.1124/dmd.121.000789
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    Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
    Lloyd Wei Tat Tang, Wan Wei, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan and Eric Chun Yong Chan
    Drug Metabolism and Disposition May 2022, 50 (5) 529-540; DOI: https://doi.org/10.1124/dmd.121.000804
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    Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A
    Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama
    Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
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    Inhibition of Human UDP-Glucuronosyltransferases1A1–Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin, and Hyperoside Is Responsible for Herb (Shuang-Huang-Lian)-Induced Jaundice
    Xiaolei Yang, Guanghao Zhu, Ying Zhang, Xubo Wu, Bei Liu, Ye Liu, Qing Yang, Wandi Du, Jingru Liang, Jiarong Hu, Ping Yang, Guangbo Ge, Weimin Cai and Guo Ma
    Drug Metabolism and Disposition May 2022, 50 (5) 552-565; DOI: https://doi.org/10.1124/dmd.121.000714
  • Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes
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    Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes
    Florian Klammers, Andreas Goetschi, Aynur Ekiciler, Isabelle Walter, Neil Parrott, Stephen Fowler and Kenichi Umehara
    Drug Metabolism and Disposition May 2022, 50 (5) 566-575; DOI: https://doi.org/10.1124/dmd.121.000765
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    Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
    Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh and Amit S. Kalgutkar
    Drug Metabolism and Disposition May 2022, 50 (5) 576-590; DOI: https://doi.org/10.1124/dmd.121.000801
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    E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice
    Zhigang Wang, Lu Gao, Shujing Ren, Guanghui Sun, Yanke Lin, Shuai Wang and Baojian Wu
    Drug Metabolism and Disposition May 2022, 50 (5) 591-599; DOI: https://doi.org/10.1124/dmd.121.000790
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    Absorption, Distribution, Metabolism, and Excretion of [14C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
    Upendra P. Dahal, Brooke M. Rock, John Rodgers, Xiaomeng Shen, Zhe Wang and Jan L. Wahlstrom
    Drug Metabolism and Disposition May 2022, 50 (5) 600-612; DOI: https://doi.org/10.1124/dmd.121.000798
  • Open Access
    Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model
    Jinfu Peng, Mayur K. Ladumor and Jashvant D. Unadkat
    Drug Metabolism and Disposition May 2022, 50 (5) 613-623; DOI: https://doi.org/10.1124/dmd.121.000733
  • Open Access
    Determination of Acyl-, O-, and N-Glucuronide Using Chemical Derivatization Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry
    Yukuang Guo, Abhi Shah, Eugene Oh, Swapan K. Chowdhury and Xiaochun Zhu
    Drug Metabolism and Disposition May 2022, 50 (5) 716-724; DOI: https://doi.org/10.1124/dmd.122.000832
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    Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota
    Keiya Hirosawa, Tatsuki Fukami, Mai Nagaoka, Masataka Nakano and Miki Nakajima
    Drug Metabolism and Disposition May 2022, 50 (5) 725-733; DOI: https://doi.org/10.1124/dmd.122.000828
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In this issue

Drug Metabolism and Disposition: 50 (5)
Drug Metabolism and Disposition
Vol. 50, Issue 5
1 May 2022
  • Table of Contents
  • Table of Contents (PDF)
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  • Special Section on Drug Metabolism in Liver Injury and Repair
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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