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Research ArticleArticle

Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama
Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
Saki Izumi
Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)
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Yoshitane Nozaki
Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)
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Wooin Lee
Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)
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Yuichi Sugiyama
Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)
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Article Information

vol. 50 no. 5 541-551
DOI 
https://doi.org/10.1124/dmd.121.000783
PubMed 
35241487

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 16, 2021
  • Accepted February 14, 2022
  • Published online April 29, 2022.

Article Versions

  • Earlier version (March 3, 2022 - 17:21).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Saki Izumi,
  2. Yoshitane Nozaki,
  3. Wooin Lee, and
  4. Yuichi Sugiyama
  1. Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)
  1. Address correspondence to:
    Dr. Saki Izumi, Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Japan. E-mail: s-izumi{at}hhc.eisai.co.jp
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Drug Metabolism and Disposition: 50 (5)
Drug Metabolism and Disposition
Vol. 50, Issue 5
1 May 2022
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Research ArticleArticle

Time-Dependent Inhibition of OATP1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama
Drug Metabolism and Disposition May 1, 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783

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Research ArticleArticle

Time-Dependent Inhibition of OATP1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama
Drug Metabolism and Disposition May 1, 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
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