Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Saki Izumi; Yoshitane Nozaki; Wooin Lee; Yuichi Sugiyama

doi:10.1124/dmd.121.000783

Research ArticleArticle

Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783

Saki Izumi

Global Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co. Ltd., Tsukuba, Japan (S.I., Y.N.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea (W.L.); and Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University, Tokyo, Japan (Y.S.)

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Yoshitane Nozaki

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Wooin Lee

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Yuichi Sugiyama

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Vol. 50, Issue 5

1 May 2022

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Research ArticleArticle

Time-Dependent Inhibition of OATP1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

Drug Metabolism and Disposition May 1, 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783

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Research ArticleArticle

Time-Dependent Inhibition of OATP1B1 by Cyclosporine A

Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

Drug Metabolism and Disposition May 1, 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783

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Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

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