Drug Metabolism and Disposition: 50 (6)

June 01, 2022; Volume 50,Issue 6

Special Section on Pharmacokinetics and ADME of Biological Therapeutics

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Special Section on Pharmacokinetics and ADME of Biological Therapeutics–Editorial
Yurong Lai and Xiao-bo Zhong

Drug Metabolism and Disposition June 2022, 50 (6) 819-821; DOI: https://doi.org/10.1124/dmd.122.000896
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Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada

Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520
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The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems
Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu

Drug Metabolism and Disposition June 2022, 50 (6) 827-836; DOI: https://doi.org/10.1124/dmd.121.000568
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Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu

Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
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A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu

Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462
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Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu

Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463
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Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics
Shufang Liu and Dhaval K. Shah

Drug Metabolism and Disposition June 2022, 50 (6) 867-878; DOI: https://doi.org/10.1124/dmd.121.000460
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Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou

Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418
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Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong

Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

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Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ⁹-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ⁹-THC (11-OH-THC)
Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat

Drug Metabolism and Disposition June 2022, 50 (6) 734-740; DOI: https://doi.org/10.1124/dmd.122.000868
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Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan

Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864
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Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model
Casey Radice, Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition June 2022, 50 (6) 750-761; DOI: https://doi.org/10.1124/dmd.122.000831
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Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour

Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780
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Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
Raymond K. Hau, Robert R. Klein, Stephen H. Wright and Nathan J. Cherrington

Drug Metabolism and Disposition June 2022, 50 (6) 770-780; DOI: https://doi.org/10.1124/dmd.121.000748
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Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [¹⁴C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao

Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
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Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao

Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

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