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Index by author

June 01, 2022; Volume 50,Issue 6

A

  1. Achour, Brahim

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

  2. Agarwal, Sagar

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Agarwal, Saket

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  4. Al-Majdoub, Zubida M.

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

  5. Alhamadani, Feryal

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418

  6. Alrubia, Sarah

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

  7. Aluri, Krishna

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  8. Anoshchenko, Olena

    1. Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)
      Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2022, 50 (6) 734-740; DOI: https://doi.org/10.1124/dmd.122.000868

  9. Arciprete, Michael

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

B

  1. Bahal, Raman

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418
    2. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  2. Ball, Kathryn

    1. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

  3. Barber, Jill

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

  4. Berna, Michael

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  5. Bolleddula, Jayaprakasam

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461

  6. Brady, Kevin

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461

  7. Brown, Christopher

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  8. Bruin, Gerard

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

C

  1. Castellanos-Rizaldos, Elena

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Charisse, Klaus

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Chen, Xiaoyan

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  4. Chen, Zhendong

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  5. Cherrington, Nathan J.

    1. Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
      Raymond K. Hau, Robert R. Klein, Stephen H. Wright and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2022, 50 (6) 770-780; DOI: https://doi.org/10.1124/dmd.121.000748

  6. Chong, Saeho

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  7. Cichocki, Joseph

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  8. Couto, Narciso

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

D

  1. Diao, Xingxing

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

E

  1. Enoki, Yuki

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  2. Escandón, Enrique

    1. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

F

  1. Fitzgerald, Kevin

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Funk, Christoph

    1. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

G

  1. Goel, Varun

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Gogate, Anagha

    1. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  3. Gu, Jingkai

    1. The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems
      Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
      Drug Metabolism and Disposition June 2022, 50 (6) 827-836; DOI: https://doi.org/10.1124/dmd.121.000568

  4. Gu, Yongli

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  5. Guenther, Dale

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  6. Gui, LanLan

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  7. Guo, Zitao

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

H

  1. Habtemariam, Bahru

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Hamada, Akinobu

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  3. Hau, Raymond K.

    1. Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
      Raymond K. Hau, Robert R. Klein, Stephen H. Wright and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2022, 50 (6) 770-780; DOI: https://doi.org/10.1124/dmd.121.000748

  4. Hauri, Simon

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  5. Hayashi, Yukitaka

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  6. Hengel, Shawna

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  7. Hu, YiTing

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  8. Huang, Qi

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

J

  1. Jadhav, Vasant

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Janas, Maja

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Jayaraman, Muthusamy

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  4. Jia, Wei

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  5. Jian, Wenying

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

K

  1. King, Lloyd

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  2. Klein, Robert R.

    1. Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
      Raymond K. Hau, Robert R. Klein, Stephen H. Wright and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2022, 50 (6) 770-780; DOI: https://doi.org/10.1124/dmd.121.000748

  3. Korzekwa, Ken

    1. Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model
      Casey Radice, Ken Korzekwa and Swati Nagar
      Drug Metabolism and Disposition June 2022, 50 (6) 750-761; DOI: https://doi.org/10.1124/dmd.122.000831

  4. Kumar, Aditya R.

    1. Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)
      Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2022, 50 (6) 734-740; DOI: https://doi.org/10.1124/dmd.122.000868

  5. Kurz, Jeffrey

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

L

  1. Lai, Yurong

    1. Special Section on Pharmacokinetics and ADME of Biological Therapeutics–Editorial
      Yurong Lai and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 819-821; DOI: https://doi.org/10.1124/dmd.122.000896

  2. Lan, Ke

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  3. Lee, Anthony

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461

  4. Li, Guangze

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  5. Li, Jing

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  6. Lin, Hongda

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  7. Liou, Steven

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  8. Liu, Anna

    1. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  9. Liu, Changxiao

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  10. Liu, Ju

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  11. Liu, Mengling

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  12. Liu, Shufang

    1. Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics
      Shufang Liu and Dhaval K. Shah
      Drug Metabolism and Disposition June 2022, 50 (6) 867-878; DOI: https://doi.org/10.1124/dmd.121.000460

  13. Liu, Sunna

    1. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  14. Liu, Xiumin

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

M

  1. Ma, Sheng

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  2. Maclauchlin, Chris

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Maier, Martin

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  4. Manautou, José E.

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418
    2. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  5. Manoharan, Muthiah

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  6. Martin, Jennifer A.

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461

  7. Matsumoto, Kazuaki

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  8. McDougall, Robin

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  9. Meng, Jian

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  10. Miao, Jia

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  11. Miao, Liyan

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  12. Migliorati, Julia M.

    1. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

N

  1. Nagar, Swati

    1. Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model
      Casey Radice, Ken Korzekwa and Swati Nagar
      Drug Metabolism and Disposition June 2022, 50 (6) 750-761; DOI: https://doi.org/10.1124/dmd.122.000831

  2. Nair, Jayaprakash K.

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Nair, Sreenidhi

    1. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

O

  1. Ohuchi, Mayu

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

P

  1. Pang, Yiling

    1. The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems
      Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
      Drug Metabolism and Disposition June 2022, 50 (6) 827-836; DOI: https://doi.org/10.1124/dmd.121.000568

  2. Parikh, Rajvi

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418

  3. Patilea-Vrana, Gabriela I.

    1. Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)
      Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2022, 50 (6) 734-740; DOI: https://doi.org/10.1124/dmd.122.000868

  4. Pereira, Joao N.S.

    1. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

R

  1. Radice, Casey

    1. Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model
      Casey Radice, Ken Korzekwa and Swati Nagar
      Drug Metabolism and Disposition June 2022, 50 (6) 750-761; DOI: https://doi.org/10.1124/dmd.122.000831

  2. Ramsden, Diane

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Rasmussen, Theodore P.

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418
    2. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  4. Robbie, Gabriel

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  5. Rostami-Hodjegan, Amin

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

S

  1. Schmidt, Karyn

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Shah, Dhaval K.

    1. Mathematical Models to Characterize the Absorption, Distribution, Metabolism, and Excretion of Protein Therapeutics
      Shufang Liu and Dhaval K. Shah
      Drug Metabolism and Disposition June 2022, 50 (6) 867-878; DOI: https://doi.org/10.1124/dmd.121.000460

  3. Shan, Lin

    1. The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems
      Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
      Drug Metabolism and Disposition June 2022, 50 (6) 827-836; DOI: https://doi.org/10.1124/dmd.121.000568

  4. Smith, Peter

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

T

  1. Taguchi, Kazuaki

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  2. Theile, Christopher

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Tillmann, Annika

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

  4. Tran, John C.

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

U

  1. Unadkat, Jashvant D.

    1. Characterizing and Quantifying Extrahepatic Metabolism of (−)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC)
      Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
      Drug Metabolism and Disposition June 2022, 50 (6) 734-740; DOI: https://doi.org/10.1124/dmd.122.000868

V

  1. Vaishnaw, Akshay

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Vasilogianni, Areti-Maria

    1. Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
      Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
      Drug Metabolism and Disposition June 2022, 50 (6) 762-769; DOI: https://doi.org/10.1124/dmd.121.000780

W

  1. Waldron, Scott

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  2. Walles, Markus

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  3. Wang, CuiTong

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  4. Wei, Cong

    1. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  5. Wei, Wei

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  6. Wright, Stephen H.

    1. Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
      Raymond K. Hau, Robert R. Klein, Stephen H. Wright and Nathan J. Cherrington
      Drug Metabolism and Disposition June 2022, 50 (6) 770-780; DOI: https://doi.org/10.1124/dmd.121.000748

  7. Wu, Hangyu

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418

  8. Wu, Jing-Tao

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  9. Wu, QingLiang

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  10. Wu, Yali

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

X

  1. Xu, Keyang

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  2. Xu, Yuanxin

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  3. Xue, Yaru

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

Y

  1. Yagishita, Shigehiro

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  2. Yamada, Hotaka

    1. Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Augmented Clearance of Nivolumab Is Associated with Renal Functions in Chronic Renal Disease Model Rats
      Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
      Drug Metabolism and Disposition June 2022, 50 (6) 822-826; DOI: https://doi.org/10.1124/dmd.121.000520

  3. Yang, Tong-Yuan

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

  4. Yin, Lei

    1. The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems
      Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
      Drug Metabolism and Disposition June 2022, 50 (6) 827-836; DOI: https://doi.org/10.1124/dmd.121.000568

  5. Yu, Hongbin

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper
      Kathryn Ball, Gerard Bruin, Enrique Escandón, Christoph Funk, Joao N.S. Pereira, Tong-Yuan Yang and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 858-866; DOI: https://doi.org/10.1124/dmd.121.000463

  6. Yu, Jinghua

    1. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

Z

  1. Zeng, WuShuang

    1. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
      QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
      Drug Metabolism and Disposition June 2022, 50 (6) 741-749; DOI: https://doi.org/10.1124/dmd.122.000864

  2. Zhan, Yan

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  3. Zhang, Hua

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  4. Zhang, Kristy

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418

  5. Zhang, Xuemei

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

  6. Zhang, Zhe

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581

  7. Zheng, Yuandong

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  8. Zhong, Dafang

    1. Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
      Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 798-808; DOI: https://doi.org/10.1124/dmd.121.000581
    2. Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
      Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
      Drug Metabolism and Disposition June 2022, 50 (6) 809-818; DOI: https://doi.org/10.1124/dmd.121.000582

  9. Zhong, Xiao-bo

    1. Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P. Rasmussen, Raman Bahal, Xiao-bo Zhong and José E. Manautou
      Drug Metabolism and Disposition June 2022, 50 (6) 879-887; DOI: https://doi.org/10.1124/dmd.121.000418
    2. Special Section on Pharmacokinetics and ADME of Biological Therapeutics–Editorial
      Yurong Lai and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 819-821; DOI: https://doi.org/10.1124/dmd.122.000896
    3. Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
      Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou and Xiao-bo Zhong
      Drug Metabolism and Disposition June 2022, 50 (6) 888-897; DOI: https://doi.org/10.1124/dmd.121.000417

  10. Zhu, Xiaochun

    1. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
      Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony Lee, Jennifer A. Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
      Drug Metabolism and Disposition June 2022, 50 (6) 837-845; DOI: https://doi.org/10.1124/dmd.121.000461
    2. A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
      Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
      Drug Metabolism and Disposition June 2022, 50 (6) 846-857; DOI: https://doi.org/10.1124/dmd.121.000462

  11. Zlatev, Ivan

    1. The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <em>N</em>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Open Access
      The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human
      Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
      Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428
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