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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human

Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
Drug Metabolism and Disposition June 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428

Article Information

vol. 50 no. 6 781-797
DOI 
https://doi.org/10.1124/dmd.121.000428
PubMed 
34154993
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 16, 2021
  • Accepted June 10, 2021
  • Published online June 6, 2022.

Article Versions

Copyright & Usage 
Copyright © 2022 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Robin McDougall1,
  2. Diane Ramsden1,
  3. Sagar Agarwal,
  4. Saket Agarwal,
  5. Krishna Aluri,
  6. Michael Arciprete,
  7. Christopher Brown,
  8. Elena Castellanos-Rizaldos,
  9. Klaus Charisse,
  10. Saeho Chong,
  11. Joseph Cichocki,
  12. Kevin Fitzgerald,
  13. Varun Goel,
  14. Yongli Gu,
  15. Dale Guenther,
  16. Bahru Habtemariam,
  17. Vasant Jadhav,
  18. Maja Janas,
  19. Muthusamy Jayaraman,
  20. Jeffrey Kurz,
  21. Jing Li,
  22. Ju Liu,
  23. Xiumin Liu,
  24. Steven Liou,
  25. Chris Maclauchlin,
  26. Martin Maier,
  27. Muthiah Manoharan,
  28. Jayaprakash K. Nair,
  29. Gabriel Robbie,
  30. Karyn Schmidt,
  31. Peter Smith,
  32. Christopher Theile,
  33. Akshay Vaishnaw,
  34. Scott Waldron,
  35. Yuanxin Xu,
  36. Xuemei Zhang,
  37. Ivan Zlatev, and
  38. Jing-Tao Wu
  1. Alnylam Pharmaceuticals, Cambridge, Massachusetts
  1. Address correspondence to:
    Jing-Tao Wu, Drug Metabolism and Pharmacokinetics, Early Development, Alnylam Pharmaceuticals Inc., 675 W Kendall St., Cambridge, MA 02142. E-mail: jtwu{at}alnylam.com
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Jul 2021152238695
Aug 20219140295
Sep 20218400253
Oct 20219140329
Nov 20218710362
Dec 20218240330
Jan 202210090371
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Predictable Cross-Species Translation of GalNAc-Conjugated siRNA

Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
Drug Metabolism and Disposition June 1, 2022, 50 (6) 781-797; DOI: https://doi.org/10.1124/dmd.121.000428
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