Fomivirsen | Intravitreal injection | Local eye | No | Retina, iris; systemic exposure: minimal (below limits of quantitation) | Very low |
Pegaptanib | Intravitreal injection | Local eye | No | Vitreous fluid, retina, aqueous fluid; systemic exposure: kidney | Slowly absorbed into systemic circulation |
Nusinersen | Intrathecal injection | CNS and systematic | Yes | CNS, plasma, peripheral tissue (skeletal muscle, liver, kidney), fat, bone marrow, spleen | 1.7–6 |
Mipomersen | S.C. injection | Systematic | No | Liver, kidney, bone marrow, adipose tissue, lymph nodes | 3–4 |
Inotersen | S.C. injection | Systematic | No | Liver, kidney, broad tissues | 2–4 |
Defibrotide | I.V. infusion | Systematic | No | Cells lining blood vessel in liver | 2 |
Eteplirsen | I.V. infusion | Systematic | No | Kidney, skeletal muscles | 1–2 |
Golodirsen | I.V. infusion | Systematic | No | Kidney, all tissue except CNS | 1 |
Viltolarsen | I.V. infusion | Systematic | No | Kidney, skeletal muscle | 1 |
Casimersen | I.V. infusion | Systematic | No | Kidney, skeletal muscle | 1 |