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Table of Contents

July 01, 2022; Volume 50,Issue 7

Special Section on Drug Metabolism and Regulation

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Special Section on Drug Metabolism and Regulation—Editorial
Xiao-bo Zhong and Yurong Lai

Drug Metabolism and Disposition July 2022, 50 (7) 998-999; DOI: https://doi.org/10.1124/dmd.122.000925
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Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds
Tsuneo Omura

Drug Metabolism and Disposition July 2022, 50 (7) 1000-1001; DOI: https://doi.org/10.1124/dmd.122.000891
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Searching for Constitutive Androstane Receptor Modulators
Paavo Honkakoski

Drug Metabolism and Disposition July 2022, 50 (7) 1002-1009; DOI: https://doi.org/10.1124/dmd.121.000482
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Clinical Relevance of the Constitutive Androstane Receptor
Sydney Stern, Ritika Kurian and Hongbing Wang

Drug Metabolism and Disposition July 2022, 50 (7) 1010-1018; DOI: https://doi.org/10.1124/dmd.121.000483
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Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development
Kouichi Yoshinari and Ryota Shizu

Drug Metabolism and Disposition July 2022, 50 (7) 1019-1026; DOI: https://doi.org/10.1124/dmd.121.000481
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From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function
Lars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. Kaminski

Drug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478

Articles

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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses
Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. Graziano

Drug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
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Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays
Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan Chu

Drug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
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The Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In Vitro
Natalia Mast, Anna Fotinich and Irina A. Pikuleva

Drug Metabolism and Disposition July 2022, 50 (7) 923-930; DOI: https://doi.org/10.1124/dmd.122.000874
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Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A
Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan

Drug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)
Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. Ronaldson

Drug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
Open Access
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework
Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud Jamei

Drug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
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Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition July 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823
Open Access
Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. Chothe

Drug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
Open Access
Metabolism and Disposition of [¹⁴C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors
Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury

Drug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
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Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882