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Drug Metabolism & Disposition

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Table of Contents

July 01, 2022; Volume 50,Issue 7

Special Section on Drug Metabolism and Regulation

  • You have access
    Special Section on Drug Metabolism and Regulation—Editorial
    Xiao-bo Zhong and Yurong Lai
    Drug Metabolism and Disposition July 2022, 50 (7) 998-999; DOI: https://doi.org/10.1124/dmd.122.000925
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    Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds
    Tsuneo Omura
    Drug Metabolism and Disposition July 2022, 50 (7) 1000-1001; DOI: https://doi.org/10.1124/dmd.122.000891
  • You have access
    Searching for Constitutive Androstane Receptor Modulators
    Paavo Honkakoski
    Drug Metabolism and Disposition July 2022, 50 (7) 1002-1009; DOI: https://doi.org/10.1124/dmd.121.000482
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    Clinical Relevance of the Constitutive Androstane Receptor
    Sydney Stern, Ritika Kurian and Hongbing Wang
    Drug Metabolism and Disposition July 2022, 50 (7) 1010-1018; DOI: https://doi.org/10.1124/dmd.121.000483
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    Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development
    Kouichi Yoshinari and Ryota Shizu
    Drug Metabolism and Disposition July 2022, 50 (7) 1019-1026; DOI: https://doi.org/10.1124/dmd.121.000481
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    From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function
    Lars C. Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M. Kaminski
    Drug Metabolism and Disposition July 2022, 50 (7) 1027-1041; DOI: https://doi.org/10.1124/dmd.121.000478

Articles

  • Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses
    You have access
    Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses
    Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois Lehman-McKeeman, Paul Morin and Robert F. Graziano
    Drug Metabolism and Disposition July 2022, 50 (7) 898-908; DOI: https://doi.org/10.1124/dmd.121.000799
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    Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays
    Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan Chu
    Drug Metabolism and Disposition July 2022, 50 (7) 909-922; DOI: https://doi.org/10.1124/dmd.121.000807
  • The Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In Vitro
    You have access
    The Hydroxylation Position Rather than Chirality Determines How Efavirenz Metabolites Activate Cytochrome P450 46A1 In Vitro
    Natalia Mast, Anna Fotinich and Irina A. Pikuleva
    Drug Metabolism and Disposition July 2022, 50 (7) 923-930; DOI: https://doi.org/10.1124/dmd.122.000874
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    Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A
    Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan
    Drug Metabolism and Disposition July 2022, 50 (7) 931-941; DOI: https://doi.org/10.1124/dmd.122.000895
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    Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)
    Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey J. Lochhead, Hrvoje Brzica, Joshua Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P. Davis and Patrick T. Ronaldson
    Drug Metabolism and Disposition July 2022, 50 (7) 942-956; DOI: https://doi.org/10.1124/dmd.121.000781
  • Open Access
    Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework
    Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y. Bois and Masoud Jamei
    Drug Metabolism and Disposition July 2022, 50 (7) 957-967; DOI: https://doi.org/10.1124/dmd.121.000818
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    Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition July 2022, 50 (7) 968-979; DOI: https://doi.org/10.1124/dmd.121.000823
  • Open Access
    Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
    Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury and Paresh P. Chothe
    Drug Metabolism and Disposition July 2022, 50 (7) 980-988; DOI: https://doi.org/10.1124/dmd.122.000836
  • Open Access
    Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors
    Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury
    Drug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
  • Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic
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    Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic
    Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen
    Drug Metabolism and Disposition July 2022, 50 (7) 1042-1052; DOI: https://doi.org/10.1124/dmd.122.000882
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In this issue

Drug Metabolism and Disposition: 50 (7)
Drug Metabolism and Disposition
Vol. 50, Issue 7
1 Jul 2022
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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